Bacterial growth environment strongly influences the efficacy of antibiotic treatment, with slow growth often being associated with decreased susceptibility. Yet in many cases, the connection between antibiotic susceptibility and pathogen physiology remains unclear. We show that for ribosome-targeting antibiotics acting on Escherichia coli, a complex interplay exists between physiology and anti...

Chronic exposure to manganese (Mn) produces a spectrum of cognitive and behavioral deficits associated with a neurodegenerative disorder resembling Parkinson's disease. The effects of high-dose exposure to Mn in occupational cohorts and in adult rodent models of the disease are well described but much less is known about the behavioral and neurochemical effects of Mn in the developing brain. We...

BACKGROUND AND PURPOSE It is not known if there is a relationship between gender and tissue outcome in human ischemic stroke. We sought to identify whether the proportion of initially ischemic to eventually infarcted tissue was different between men and women with ischemic stroke. METHODS We studied 141 consecutive patients with acute ischemic stroke who had a baseline MRI obtained within 12 ...

Clinical strains of Stenotrophomonas (Xanthomonas) maltophilia often show large, growth temperature-dependent, variations in their susceptibility (TDVS) to aminoglycoside antibiotics. Strains showing more than a fourfold increase in susceptibility between 30 degrees and 37 degrees C (TDVS+ strains; n = 23) were contrasted with those showing lesser variation (TDVS- strains; n = 15) in studies of...

background and purpose: candida albicans is the most common causative agent of candidiasis. candidiasis management is dependent on the immune status of the host, severity of disease, and the choice of antifungal drug. antifungals, specifically triazoles, are widely administered for the treatment of invasive fungal infections. herein, we aimed to evaluate the in vitro susceptibility of c. albica...

literature and culture are two inseparable issues. when we talk about the culture, the literature can also appear unconsciously, because the culture is composed of thoughts, feelings and emotions and the styles and personal ways of society, which as a general rule, can appear in terms of principles and respectful rules. the literature on the other hand, discloses and transmits these concepts to...

Abstract DNA methylation is an epigenetic biological process that emerging as important mediator of environmental risk effects on the susceptibility severe illness, such schizophrenia. shows coordination across biologically-related genes, but it not known whether resulting network structure has a mediating effect illness risk. Here we identified large gene with hyper-coordinated in several proc...

This study investigates the antibacterial mechanism of action of electrospun chitosan-based nanofibers (CNFs), against Escherichia coli, Salmonella enterica serovar Typhimurium, Staphylococcus aureus and Listeria innocua, bacteria frequently involved in food contamination and spoilage. CNFs were prepared by electrospinning of chitosan and poly(ethylene oxide) (PEO) blends. The in vitro antibact...

Susceptibility to most human diseases is polygenic, with complex interactions between functional polymorphisms of single genes governing disease incidence, phenotype, or both. In this context, the contribution of any discrete gene is generally modest for a single individual, but may confer substantial attributable risk on a population level. Environmental exposure can modify the effects of a po...