We report the case of a 51-year-old woman who presented with bilateral progressive deterioration in vision after taking chloroquine for severe rheumatoid arthritis for 10 years. She was found to have a bull's eye pattern of depigmentation in the macula of both eyes. Despite cessation of chloroquine, her vision did not improve. The clinical presentation of chloroquine retinopathy is discussed, a...

Shah-Waardenburg syndrome (SWS) is a neurocristopathy and is characterized by Hirschsprung's disease (HD), deafness, and depigmentation of hairs, skin, and iris. Is a very rare congenital disorder with variable clinical expression. This report describes a 4-day-old male newborn with Waardenburg's syndrome associated with aganglionosis of the colon and terminal ileum, and review the relevant lit...

Pigment disorders1,3 Hypopigmentation or depigmentation. Lesions demonstrate increased sharpness of borders under Wood lamp examination and fluoresce bright blue-white owing to the increased amount of dermal collagen illuminated. This results from decreased or absent intervening melanin. Vitiligo: patches, varying in location and extent. Tuberous sclerosis: patches; characteristic shapes are la...

resents the high end of the spectrum in general vitiligo. This is represented by an extreme clinical presentation with (sub)total depigmentation, a strong familial expression of the disease, and high prevalence of comorbidity, such as thyroid dysfunction, rheumatoid arthritis, and alopecia areata. Health-related QOL is comparable to what is found in general vitiligo except for poorer functionin...

Two cases of 14q proximal partial trisomy in sisters from the same family are reported. Clinical features included craniofacial dysmorphism, skin depigmentation, slight anomalies of the limbs, muscular hypertonia, and physical and mental retardation. The third sister had an abnormal phenotype, different from that of her sibs, and proved to be a carrier of a balanced translocation (2;14)(q36;q21...

A total of 34 lids with aberrant lashes were treated with the specifically designed Collin cryoprobe without microthermocouple temperature monitoring. A high success rate of 82% was obtained. By applying the cryoprobe to the lid margin and conjunctival surface instead of to the skin it was possible to limit the degree of depigmentation in these highly pigmented lids, and only one patient showed...

Oculocutaneous albinism is a rare autosomal recessive disorder characterized by general depigmentation, nystagmus, photophobia, and decreased visual acuity. Malignant melanoma is extremely rare in patients with albinism. We present a 41-year-old albino male patient, who was admitted with a suspected bronchogenic carcinoma. He underwent a pulmonary resection and the diagnosis was primary malign ...