This article addresses an extension of the multi-depot vehicle routing problem in which vehicles may be replenished at intermediate depots along their route. It proposes a heuristic combining the adaptative memory principle, a tabu search method for the solution of subproblems, and integer programming. Tests are conducted on randomly generated instances.

BACKGROUND Nonadherence with antipsychotic medication is an important clinical and economic problem in the treatment of schizophrenia. This study identified treatment patterns and clinical characteristics that immediately precede the initiation of depot typical antipsychotics in the usual treatment of schizophrenia patients with a recent history of nonadherence with oral antipsychotic regimens....

Glucocorticoids promote fat accumulation in visceral compared to subcutaneous depots, but the molecular mechanisms involved remain poorly understood. To identify long-term changes in gene expression that are differentially sensitive or responsive to glucocorticoids in these depots, paired samples of human omental (Om) and abdominal subcutaneous (Abdsc) adipose tissues obtained from obese women ...

In this paper we introduce a new class of Pickup and Delivery problems on circles (or rings). These arise in the field public transportation systems where autonomous (i.e. driverless) vehicles travel circular networks. We consider set stations arranged circle requests. Each request asks for certain quantity from pickup station to delivery station. A fleet capacitated is available at depot. firs...

The vehicle routing with pickups and deliveries (VRPD) problem is de6ned over a graph G=(V; E). Some vertices in G represent delivery customers who expect deliveries from a depot, and other vertices in G represent pickup customers who have available supply to be picked up and transported to a depot. The objective is to 6nd a minimum length tour for a capacitated vehicle, which starts at a depot...

The adrenocorticotrophic effects of a synthetic corticotrophin analogue, alpha(1-18) ACTH with D-serine(1), lysine(17), and lysine amide(18) substitutions has been studied. It is effective after both intramuscular and subcutaneous administration and compared with tetracosactrin depot (Synacthen depot, Cortrosyn depot) it has a similarly prolonged time course of action-about 24 hours after 0.5 m...

OBJECTIVE Nonadherence is a major challenge in schizophrenia treatment. While long-acting (depot) antipsychotic medications are often recommended to address adherence problems, evidence on the comparative effectiveness of depot versus oral antipsychotics is inconsistent. We hypothesize that this inconsistency could be due to systematic differences in study design. This review evaluates the effe...

This paper deals with a real-life vehicle delivery routing problem, which is a seafood product delivery routing problem. Considering the features of the seafood product delivery routing problem, this paper formulated this problem as a multi-depot open vehicle routing problem. Since the multi-depot open vehicle routing problem is a very complex problem, a method is used to reduce the complexity ...

Abstract This paper develops new solution procedures for the order picker routing problem in U-shaped picking zones with a movable depot, which has so far only been solved using simple heuristics. The presents first exact approach, based on combinatorial Benders decomposition, as well heuristic approach dynamic programming that extends idea of venerable sweep algorithm. In computational study, ...

OBJECTIVE Non-adherence is a major problem in the treatment of schizophrenia. Depot antipsychotic drugs are thought to reduce relapse rates by improving adherence, but a systematic review of long-term studies in outpatients is not available. METHOD We searched the Cochrane Schizophrenia Group's register, ClinicalTrials.gov, Cochrane reviews on depot medication, and the reference sections of i...