disodium glycyrrhetinic acid hemiphthalaic (gap) was evaluated for developmental toxicity in pregnant nmri mice. gap was administered intrapcritoneally on days s, 9, 10, of gestation at doses of 0, 25, 50 and 75 mg/kg/dav. on gestation day of is, after operational delivery, the fetuses were examined for soft tissue, external and skeletal defects. increased absorptions, dead fetuses, and reduce ...

The use of this material under current use conditions is supported by the existing information. This material was evaluated for genotoxicity, repeated dose toxicity, developmental toxicity, reproductive toxicity, local respiratory toxicity, phototoxicity, skin sensitization potential, as well as, environmental safety. Repeated dose toxicity was determined to have the most conservative systemic ...

Explanation.................................................................................................... 161 Evaluation for acceptable daily intake .......................................................... 161 Biochemical aspects ................................................................................ 162 Absorption, distribution and excretion ......................................