Background: Postoperative shivering is an important and troublesome condition during recovery from general anesthesia.  Corticosteroids have been recommended to facilitate recovery and diminish shivering after cardiac surgery.  Previous studies recommended 0.6 mg/kg dexamethasone for reducing postoperative shivering in patients undergoing cardiac surgery.   Objective: To test this assertion, we...

Introduction: Inflammation is one of the probable causes of post-dural puncture headache (PDPH); logically, therefore, anti-inflammatory drugs such as dexamethasone can reduce the headache. The aim of this study was to evaluate the effect of intravenous dexamethasone 8 mg on PDPH in cesarean surgery. Methods: This randomized double-blind clinical study was conducted on 104 patients aged from 1...

Stress causes activation of the hypothalamic-pituitary-adrenal (HPA) axis and results in the secretion of corticosteroids, which facilitate behavioral adaptation and promote the termination of the stress response. These actions exerted by cortisol are mediated by two brain corticosteroid receptor types: the high affinity mineralocorticoid (MR) and the low affinity glucocorticoid receptor (GR). ...

The effects of dexamethasone (a synthetic glucocorticoid) and insulin on the secretion of very-low-density lipoprotein (VLDL) and high-density lipoprotein (HDL) were investigated. Rat hepatocytes in monolayer culture were preincubated for 15 h in the presence or absence of combinations of 100 nM-dexamethasone and 2 nM-, 10 nM- or 50 nM-insulin. Dexamethasone increased [3H]oleate incorporation i...

PURPOSE To compare efficacy and safety of bortezomib plus dexamethasone and vincristine plus doxorubicin plus dexamethasone (VAD) as induction before stem-cell transplantation in previously untreated myeloma. PATIENTS AND METHODS Four hundred eighty-two patients were randomly assigned to VAD (n = 121), VAD plus dexamethasone, cyclophosphamide, etoposide, and cisplatin (DCEP) consolidation (n ...

OBJECTIVES When added to local anaesthetics, dexamethasone can prolong the duration of peripheral blocks. Dexamethasone has a long and efficient glucocorticoid structure and presents anti-inflammatory properties. The aim of this study was to determine the effect of dexamethasone on the block duration added to levobupivacaine used for transversus abdominis block (TAP) applied to patients who und...

Patients with refractory or relapsed and refractory multiple myeloma who no longer receive benefit from novel agents have limited treatment options and short expected survival. del(17p) and t(4;14) are correlated with shortened survival. The phase 3 MM-003 trial demonstrated significant progression-free and overall survival benefits from treatment with pomalidomide plus low-dose dexamethasone c...

background post-operative nausea and vomiting (ponv) is one of the common problems after laparoscopic cholecystectomy. objectives the current study aimed to compare dexamethasone effect with that of granisetron in prevention of ponv. patients and methods in the current study 104 patients aged 20-60 with asa class i or ii who were candidates for laparoscopic cholecystectomy were included in the ...

introduction: ischaemic-reperfusion nerve injury has been suggested as the mechanism for post-tourniquet limb paralysis. as dexamethasone (dex) has been shown to prevent ischaemic-reperfusion process in some tissues, we tested the hypothesis that this drug would reduce tourniquet induced nerve injury. methods: 36 male wistar rats (200-250 gr) were chosen and divided randomly into 6 equal groups...

OBJECTIVE To evaluate the efficacy of dexamethasone added to the treatment of adult patients with bacterial meningitis in our region. METHODS One hundred and forty-four patients were randomized prospectively and evaluated to determine the efficacy of dexamethasone treatment in adult patients with acute bacterial meningitis at Dicle University Hospital, Diyarbakir, Turkey between January 2000 ...