protein amyloid beta (a?), as the pathologic hallmark of alzheimer disease (ad), increases in the brain of diabetic patients. the aim of this study was to investigate the effect of 6 weeks of voluntary wheel running combined with allium paradoxum extract on cortex amyloid beta (a?1-42) levels in diabetic rats induced with alloxan. for this purpose, 42 male wistar rats (weight 185+1 gr, 8 weeks ...

the aqueous extract of syzygium cumini (pulp) was investigated for its possible hypoglycemic and antioxidant potentials in streptozotocin (stz) induced diabetic wistar female rats. a single intraperitoneal injection of stz at a dose of 55 mg/kg body weight elevated the glucose levels more than 230 mg/dl after 3 days. treatment with the aqueous extract of syzygium cumini (pulp) at 100 mg/kg and ...

background boswellia serrata has been used in a wide variety of diseases, including diabetes mellitus and inflammatory diseases. objectives this study focused on the effects of boswellia serrata aqueous extract on blood glucose and the complications of diabetes in the liver and kidneys and examined the impact of plant on reproduction in diabetic rats. materials and methods the antioxidant capac...

the aim of the present study was to evaluate the effect of melatonin as an antioxidant on spatial navigation memory in male diabetic rats. thirty-two male white wistar rats weighing 200 ± 20 g were divided into four groups, randomly: control, melatonin, diabetic and melatonin-treated diabetic. experimental diabetes was induced by intraperitoneal injection of 50 mg kg-1 streptozotocin. melatonin...

angiotensin-converting enzyme (ace) inhibitors including quinapril could exert a protective effect on cardiovascular system through endothelial system in normoglycemic and diabetic rats. the present experimental work was designed to study the vascular reactivity of aortic ring segments isolated from streptozotocin (stz)-diabetic rats treated for 4 weeks with nitro-l-arginine-methyl ester (l-nam...

diabetic retinopathy is the lead among causes of blindness in north america. glucose-induced endothelial injury is the most important cause of diabetic retinopathy and other vascular complications. extracellular signal-regulated kinase 5 (erk5), also known as big mitogen-activated protein kinase 1 (bmk1), is a member of mitogen-activated protein kinases (mapk) family. physiologically, it is cri...

the present study was aimed to evaluate the therapeutic potential of pimpinella tirupatiensis (pt) by assaying the activities of selective mitochondrial enzymes in streptozotocin induced diabetic rats. diabetic rats showed a significant (p < 0.01) reduction in the activities of oxidative enzymes succinate dehydrogenase (sdh), malate dehydrogenase (mdh), glutamate dehydrogenase (gdh) and isocitr...

due to the anti-diabetic and antioxidant activity of green tea epigallocatechin-gallate (egcg), this research study was conducted to evaluate, for the first time, the efficacy of chronic treatment of egcg on alleviation of hyperalgesia in streptozotocin-diabetic (stz-diabetic) rats. male wistar rats were divided into control, diabetic, egcg-treated-control and diabetic and sodium salicylate (ss...

PURPOSE We evaluated the relationship between long-term glycemic control and the proportion of patients developing proliferative diabetic retinopathy (PDR) among cases with mild type preproliferative diabetic retinopathy (PPDR). METHODS The relationship was evaluated between the mean hemoglobin A1C (HbA1C) value during a period of at least 2 years and the proportion of patients developing PDR...

objective: this study was designed to investigate the antinociceptive effect of curcumin in diabetic rats by using the formalin and hot tail immersion tests. methods: wistar rats were divided into the following six groups:  control; curcumin-treated control (50 mg/kg); diabetic; sodium salicylate (ss)-treated diabetic; and two curcumin-treated diabetic groups (10 and 50 mg/kg). curcumin was ad...