Fibromuscular dysplasia is a non-atherosclerotic, non-inflammatory arteriopathy, considered rare cause of coronary artery disease. Although familial cases have been described, no specific gene association has detected so far. When the vessels are involved, main clinical scenarios stable angina, acute syndromes, left ventricular dysfunction, and sudden death. Specific angiographic findings may s...

diabetic foot ulcer (dfu) is considered as one of the main causes of hospitalization in diabetic patients, which can lead to infection, gangrene, amputation, and even death if the necessary care is not provided. based on the recent investigations, one of the most effective tactics to manage diabetic foot ulcer is to form a multidisciplinary team including a general practitioner, a nurse, an edu...

Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is the most common form of hereditary cerebral angiopathy. We present a case in which a pattern of diffusion signal change compatible with bihemispheric acute watershed infarcts occurred in a symptomatic patient demonstrating global hypoperfusion. To our knowledge, watershed infarcts in the clin...

The clinicopathologic features of two Japanese sisters with cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) are described. Neither patient had a history of hypertension, and both experienced cerebrovascular events before reaching their forties. Severe degenerative changes in the lumbar spine and knee joints were seen on radiographs. MRI show...

objective(s):diabetic nephropathy is an important long-term complication of diabetes mellitus which appears to be partially mediated by an increase in secretion of transforming growth factor-β (tgf-β). fibromodulin, the small leucine-rich proteoglycan, has been proposed to be the potent tgfβ1 modulator. in this study, the therapeutic effects of recombinant adenoviral vectors expressing fibromod...

BACKGROUND AND PURPOSE In children, early differentiation among various etiologies of arterial ischemic stroke (AIS) is important. Cerebral arteriopathy is a frequently identified cause of childhood stroke. Children with arteriopathies require a different therapeutic approach from children with AIS of nonarteriopathic origin. We aimed to investigate the association between temporal features of ...