Both diabetic cardiomyopathy (DCM) and baroreflex dysfunction independently contribute to sudden cardiac death (SCD), however the inherent connections between them under diabetic state remains unclear. As microRNAs (miRNAs) have been reported to participate in various physiological and pathological processes, we presume they may also be involved in DCM and DM-induced impairment of baroreflex se...

In the 45to 74-year-old group of the Framingham Study,1 heart failure (HF) was twice as common in diabetic men and five times more common in diabetic women as it was in nondiabetic subjects and in patients under age 65. HF was fourfold higher in diabetic males and eightfold higher in diabetic females. In a health maintenance organization of almost 10,000 type 2 diabetic subjects, 12% initially ...

Sitagliptin, a dipeptidyl peptidase-4 inhibitor, has been reported to promote cardioprotection in diabetic hearts by limiting hyperglycemia and hyperlipidemia. However, little is known about the involvement of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway modulation in the cardioprotective effects of sitagliptin. The current study aimed to investigate the ...

To understand cardiac dysfunction in diabetes, the activity of protein kinase C (PKC) and protein contents of its isozymes (PKC-α, -β, -ε, and -ζ) were examined in diabetic rats upon injection of streptozotocin (65 mg/kg iv). The hearts were removed at 1, 2, 4, and 8 wk, and some of the 6-wk diabetic animals had been injected with insulin (3 U/day) for 2 wk. The Ca2+-dependent PKC activity was ...

BACKGROUND Recent evidence indicates that inhibition of histone deacetylase (HDAC) protects the heart against myocardial injury and stimulates endogenous angiomyogenesis. However, it remains unknown whether HDAC inhibition produces the protective effect in the diabetic heart. We sought to determine whether HDAC inhibition preserves cardiac performance and suppresses cardiac remodeling in diabet...

BACKGROUND Diabetic patients are more sensitive to myocardial ischemic injury than non-diabetic patients. Silent information regulator 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent histone deacetylase making the heart more resistant to ischemic injury. As SIRT1 expression is considered to be reduced in diabetic heart, we therefore hypothesized that up-regulation of SIRT1 in the dia...

conclusions our findings revealed that the severity of coronary artery stenosis is common in diabetic patients compared to nondiabetics. early diagnosis and treatment of cad in diabetic patients is recommended. results based on data found in our study, 93.8% of diabetic and 83.4% of nondiabetic patients were shown to suffer coronary artery stenosis. severe involvement (grade 3vd) of coronary ar...