Chronic hyperglycaemia (an abnormally high glucose concentration in the blood) resulting from defects in insulin secretion/action, or both, is the major hallmark of diabetes in which it is known to be involved in the progression of the condition to different complications that include diabetic neuropathy. Diabetic neuropathy (diabetes-induced nerve damage) is the most common diabetic complicati...

We hypothesized that sera from type 2 diabetic patients with neuropathy contains an autoimmune immunoglobulin that promotes complement-independent, calcium-dependent apoptosis in neuronal cell lines. Neuronal cells were cultured in the presence of complement-inactivated sera obtained from patients with type 2 diabetes with and without neuropathy and healthy adult control patients. Serum from di...

Corresponding author: Min Young Chung Division of Endocrinology and Metabolism, Department of Internal Medicine, Chonnam National University Medical School, 8 Hak-dong, Dong-gu, Gwangju 501-757, Korea E-mail: [email protected] We appreciate the interest and comments on our study, “Association between diabetic polyneuropathy and cardiovascular complications in type 2 diabetic patients,” whic...

OBJECTIVE To determine if improved foot sensitivity to the Semmes-Weinstein 10-g (5.07) monofilament, originally impaired because of diabetic peripheral neuropathy, might be associated with a reduced incidence of new diabetic foot wounds. DESIGN Retrospective cohort study using a health status questionnaire. SUBJECTS Sixty-eight individuals over age 64 with diabetes, diabetic peripheral neu...

The National Institute of Diabetes and Digestive and Kidney Diseases sponsored a meeting recently to explore new ways to assess diabetic retinopathy and neuropathy, both in diabetic patients and in diabetic mice. The workshop compared current gold standards for assessment of retinopathy and neuropathy, new improvements of existing techniques, and new functional biomarkers measured with nontradi...

Altered sorbitol and myo-inositol metabolism, (Na,K)-ATPase function, electrochemical sodium gradients, axonal swelling, and distortion and disruption of the node of Ranvier ("axo-glial dysjunction") directly implicate hyperglycemia in the pathogenesis of neuropathy in diabetic rats, but the relevance of this sequence to clinical neuropathy in heterogeneous groups of diabetic patients remains t...

objective: diabetic neuropathy is the most common complication of diabetes mellitus affecting the nervous system. in this study, we investigated the in vivo effects of combined administration of 4-methylcatechol (4-mc) and progesterone (p) as a potential therapeutic tool for sciatic nerve function improvement and its role in histomorphological alterations in diabetic neuropathy in rats. materia...

BACKGROUND Diabetic neuropathy and idiopathic neuropathy are among the most prevalent neuropathies in human patients. The molecular mechanism underlying pathological changes observed in the affected nerve remains unclear but one candidate molecule, the receptor for advanced glycation end-products (RAGE), has recently gained attention as a potential contributor to neuropathy. Our previous studie...