In this issue of Diabetes, Chen et al. (1) used rodent models of type 1 diabetes and ischemia-induced retinal neovascularization to examine how the lipidlowering drug fenofibrate may prevent progression of diabetic retinopathy. Diabetic retinopathy is the sightthreatening complication of diabetes that causes retinal microvascular dysfunction, which in turn leads to diabetic macular edema (DME),...

Complex carbohydrate substances have been demonstrated histologically in hyaline material present in the glomerular and retinal capillary lesions which develop in diabetic patients. There has been increasing speculation that the source of this material might be polysaccharides present in abnormal amounts in the blood of such individuals (1-3). Hitherto, however, the glycoproteins in the sera of...

The incidence of wound related complication following total knee arthroplasty is as high as 10%-20%. To perform total knee arthroplasty in a knee with extensive scarring around the knee can be a challenging task. We report a case of 55-year-old diabetic woman, who had total knee arthroplasty, performed two years after she had recovered from necrotizing fasciitis around the right knee. Understan...

Diabetic retinopathy is a sight-threatening complication of diabetes, affecting 65% of patients after 10 years of the disease. Diabetic metabolic insult leads to chronic low-grade inflammation, retinal endothelial cell loss and inadequate vascular repair. This is partly due to bone marrow (BM) pathology leading to increased activity of BM-derived pro-inflammatory monocytes and impaired function...

Diabetic retinopathy (DR) is a most severe microvascular complication which, if left unchecked, can be sight-threatening. With the global prevalence of diabetes being relentlessly projected to rise to 438 million subjects by 2030, DR will undoubtedly pose a major public health concern. Efforts to unravel the human genetics of DR have been undertaken using the candidate gene and linkage approach...

The vascular complications, their management and results of treatment in 417 consecutive renal transplantations performed at Taleghani Hospital from September 1989 to December 1997, are presented. There were 7 (1.6%) vascular complications. Among them renal artery stenosis occurred in 2 cases (0.4%), renal artery thrombosis in 2 cases (0.4%), renal vein thrombosis in one case (0.2%), bleed...

Dec 2009 were studied. Patients with vascular injuries caused by causes other than tear gas shells were excluded from the study. Results: All patients were treated with reverse saphenous vein graft as segmental loss was less than 2.5 cm. Wound infection was the most common complication, followed by graft occlu-sion. Amputation rate was 16.66%. Associated nerve injury occurred in 44.44% ...