background and aims. well-differentiated chondrosarcoma and enchondroma are similar in histopathologic aspects; therefore, special methods should be used to make a distinction between these benign and malignant tumors. the aim of this study was to evaluate the efficacy of a histopathologic method in the long-term follow-up for differentiating these lesions. materials and methods. the medical re...

objectives to evaluate predictive value of vessel specific coronary artery calcium (cac) score in predicting obstructive coronary artery disease. patients and methods in this diagnostic test study we evaluated patients with coronary computed tomography angiography (ccta) and cac score which had been referred to two referral radiology center in tehran, iran and finally we selected 2525 patients ...

A clinical trial was undertaken to evaluate the Anti depressant efficacy of Newer Antidepressant Mirtazapine in the treatment of major Depression in 39 patients in an O.P.D. setup. In addition to this clinical acceptability and safety profile of Mirtazapine as compared to that of Amitriptyline was also assessed. Mitazapine usually described as Noradrenergic and specific serotonergic Anti depres...

Rucaparib camsylate (CO-338, AG-014699, PF-01367338) is a potent PARP-1, PARP-2, and PARP-3 inhibitor. Phase I and II studies demonstrated clinical efficacy in both BRCA-mutated (inclusive of germline and somatic) ovarian tumors and ovarian tumors with homologous recombination deficiency (HRD) loss of heterozygosity (LOH). Rucaparib has received the US Food and Drug Administration (FDA) approva...

BACKGROUND In drug development, a 4-phase hierarchical model for the clinical evaluation of new pharmaceuticals is well known. Several comparable phased evaluation schemes have been proposed for medical tests. PURPOSE To perform a systematic search of the literature, a synthesis, and a critical review of phased evaluation schemes for medical tests. DATA SOURCES Literature databases of Medli...

OBJECTIVE Concentrating on oncogenic role and increased plasma expression of microRNA(miR) 106b~25 clusters (involving miR 106b, miR 93 and miR 25), we evaluated significance of the over-expression of plasma miR 106b~25 in GC. METHODS Based on 65 pairs matched GC patients and health controls, we explored clinical significance of miR 106b~25 for GC and compared their diagnostic performance wit...

OBJECTIVES The diagnostic efficacy of sentinel lymph node biopsy(SLNB) in early oral squamous cell carcinoma(OSCC) still remains controversial. This meta-analysis was conducted to assess the diagnostic value of SLNB in clinically neck-negative T1-2 OSCC. METHODS A systematic literature search for relevant literature published up to September 11, 2016 was conducted in PubMed, Embase, Web of Sc...