Scaffold proteins organize many MAP kinase pathways by interacting with several components of these cascades. Recent studies suggest that scaffold proteins provide local activation platforms that contribute to signal specificity by insulating different MAP kinase pathways.

Quantum state resolved reactivity measurements probe the role of vibrational symmetry on the vibrational activation of the dissociative chemisorption of CH4 on Ni(111). IR-IR double resonance excitation in a molecular beam was used to prepare CH4 in three different vibrational symmetry components, A1, E, and F2, of the 2ν3 antisymmetric stretch overtone vibration as well as in the ν1+ν3 symmetr...

background: preeclampsia is the most prevalent complication of pregnancy and one ihird cause of death in pregnant women. developing of a screening test may help to early diagnosis. this study performed to compare diagnostic value of the roll over test and hematocrit level in early detection of preeclampsia.        methods: 660 pregnant women with gestational age of 24-28 weeks referred totamin ...

Diagnostic accuracy studies are fundamental for the assessment of diagnostic tests. Researchers need to understand implications their chosen design, opting comparative designs where possible. should analyse test using appropriate methods, acknowledging uncertainty results and avoiding overstating conclusions ignoring clinical situation which inform trade-off between sensitivity specificity. Tes...

Background: The most often fractured bone among the tarsal bones is calcaneum. first assessment of suspected calcaneum fracture conventional radiography. modern calcaneal fractures mainly based on multidetector computed tomography, because its three-dimensional nature and Volume rendering techniques. objective this study was to compare diagnostic value Multidetector CT with Conventional radiogr...

Clustered protocadherin (Pcdh) proteins mediate dendritic self-avoidance in neurons via specific homophilic interactions in their extracellular cadherin (EC) domains. We determined crystal structures of EC1-EC3, containing the homophilic specificity-determining region, of two mouse clustered Pcdh isoforms (PcdhγA1 and PcdhγC3) to investigate the nature of the homophilic interaction. Within the ...

Depending on the degree to which the original study context is accessible, selective memory retrieval can be detrimental or beneficial for the recall of other memories (Bäuml & Samenieh, 2012). Prior work has shown that the detrimental effect of memory retrieval is typically recall specific and does not arise after restudy trials, whereas recall specificity of the beneficial effect has not been...

Urine of 30 pregnant females was tested for gravidex test. Both concentration and agglutination inhibition (Beta monoclonal) tests were performed on the same urine specimens. Results showed that the sensitivity and specificity of the concentration (colour) test was much higher than that of the B monoclonal test.