INTRODUCTION Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions. CASE REPORT A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold wit...

PURPOSE To compare enhancement characteristics and image quality of two macrocyclic gadolinium chelates, gadoterate meglumine and gadobutrol, in low-dose, time-resolved MRA of the calf station. MATERIALS AND METHODS 100 consecutive patients with peripheral arterial disease (stages II-IV) were retrospectively analysed. Fifty patients were included in each group - 32 men and 18 women for gadobu...

The antimonial drug, meglumine antimoniate, was successfully encapsulated in dehydration-rehydration vesicles and in freeze-dried empty liposomes (FDELs). High encapsulation efficiencies (from 28 to 58%) and low weight ratios of lipids to encapsulated antimony (from 1:0.15 to 1:0.3) were achieved. These formulations, contrary to those obtained by conventional methods, can be stored as intermedi...

Although New World cutaneous leishmaniasis is not itself a life-threatening disease, its treatment with systemic antimonials can cause toxicity that can be dangerous to some patients. Intralesional meglumine antimoniate provides a viable, less toxic alternative. Herein, we describe an alternative treatment with subcutaneous intralesional injections of meglumine antimoniate into large periarticu...

The electrocatalytic oxidation of meglumine and gadoterate (Gd-DOTA) on a TiO2-Ni(SO4)0.3(OH)1.4 composite anode was investigated in alkaline medium (5 M KOH) using cyclic voltammetry chronoamperometry. prepared by hydrothermal method the morphology structure produced nanoparticles were studied scanning electron microscopy with energy-dispersive X-ray spectroscopy, diffraction, atomic force mic...

The favorable outcome of the treatment of a disease is influenced by the adherence to therapy. Our objective was to assess factors associated with adherence to treatment of patients included in a clinical trial of equivalence between the standard and alternative treatment schemes with meglumine antimoniate (MA) in the treatment of cutaneous leishmaniasis (CL), in the state of Rio de Janeiro. Be...

Introduction: Peptic ulcer disease is still the major cause of gastro-intestinal perforation despite major improvements in both diagnostic and therapeutic strategies. While the diagnosis of a perforated ulcer is straightforward in typical cases, its clinical onset may be subtle because of co-morbidites and/or concurrent therapies. Case presentation: We report a case of a 53-year-old Caucasian m...

the head for evaluation of memory loss. She received 100 ml of diatrizoate meglumine (Angiovist 282), an intravenous RCM. The patient had never previously been exposed to RCM and within 1 mm of its administration, she complained of severe dyspnea and a sensation of fullness in her neck, as if someone were choking her. The radiologist evaluating the patient did not report evidence of facial swel...

1. Flunixin is a non-steroidal anti-inflammatory drug (NSAID), and a non-narcotic analgesic with antipyretic activities. In veterinary medicine, it is used with meglumine as solubilizer as flunixin meglumine. Flunixin meglumine is used in the alleviation of inflammation and pain associated with musculo-skeletal disorders and colic in horses; the control of acute inflammation associated with inf...

AIM To determine the effects of high osmolarity contrast media (HOCM) and iso-osmolar contrast media (CM) application, with or without pressure, on hepato-pancreato-biliary (HPB) system. METHODS Sixty rats were divided into six equal groups as follows: Group 1: (0.9% NaCl, control), Group 2: (diatrizoate meglumine Na, ionic HOCM, Urographin), Group 3: (iodixanol, iso-osmolar non-ionic CM, Vis...