Distinct subsets of sensory nerve fibres are involved in mediating mechanical and thermal pain hypersensitivity. They may also differentially respond to analgesics. Heat-sensitive C-fibres, for example, are thought to respond to μ-opioid receptor (MOR) activation while mechanoreceptive fibres are supposedly sensitive to δ-opioid receptor (DOR) or GABAB receptor (GABABR) activation. The suggeste...

changes in moisture content and temperature can perturb both stiffness and strength and as such the impact resistance of composite structures. in this paper, the pre-notched basalt fibre reinforced epoxy (bfre) composite specimens are studied under charpy impact loads in order to investigate the changes in impact energy absorption (fracture toughness) with different kinds of aging conditions. t...

There is increasing evidence that fibre size and shape play an important part in the production of health effects related to asbestos. The dimensions of airborne fibres collected at various stages of fibre processing in three mines and six mills producing three types of asbestos were measured using phase contrast light microscopy and transmission electron microscopy. Airborne fibres of differen...

Abstract The establishment of sustainable bioeconomies requires the utilization new renewable biomaterials. One such material currently seen as a waste product is oat hulls. Oat hulls exhibit great potential for production dietary fibres due to their exceptionally large hemicellulose content (35%). Their recalcitrant structure however suitable pre-treatment method access and process hemicellulo...

The purpose of the present study was to determine the relationships between the changes of myofibrils in fast-twitch oxidative-glycolytic (type IIA) fibres and fast-twitch glycolytic (type IIB) muscle fibres, protein synthesis and degradation rate in exercise-induced myopathic skeletal muscle. Exhaustive exercise was used to induce myopathy in Wistar rats. Intensity of glycogenolysis in muscle ...

We have compared the density of nerve fibres in the synovium in club foot with that of specimens obtained from the synovium of the hip at operations for developmental dysplasia. The study focused on the sensory neuropeptides substance P; calcitonin gene-related peptide; protein gene product 9.5, a general marker for mature peripheral nerve fibres; and growth associated protein 43, a neuronal ma...

Little is known about the contribution of C-afferent fibres to chronic painful conditions in humans. We sought to investigate the role of C-fibres in the pathophysiology of pain and hyperalgesia in erythromelalgia as a model disease for chronic pain. Erythromelalgia is a condition characterized by painful, red and hot extremities, and patients often report tenderness on walking. We made microne...

Skeletal muscles are composed of fibres of different types, each type being identified by the isoform of myosin heavy chain which is expressed as slow 1, fast 2A, fast 2X, and fast 2B. Slow fibres are resistant to fatigue due to their highly oxidative metabolism whereas 2X and 2B fibres are easily fatiguable and fast 2A fibres exhibit intermediate fatigue resistance. Slow fibres and fast fibres...