Peripheral blood film review refers to checking or verifying flagged or abnormal results obtained by an automated hematology analyzer. The usual mechanism for this review is to have an expert human inspect a stained blood film with identification and enumeration of 100 or more consecutive leukocytes. This function also includes inspection of red cell and platelet morphology with comments and in...

Hemocytes synthesize key components of the mosquito complement-like system, but their role in the activation of antiplasmodial responses has not been established. The effect of activating Toll signaling in hemocytes on Plasmodium survival was investigated by transferring hemocytes or cell-free hemolymph from donor mosquitoes in which the suppressor cactus was silenced. These transfers greatly e...

The lymph gland is a specialized organ for hematopoiesis, utilized during larval development in Drosophila. This tissue is composed of distinct cellular domains populated by blood cell progenitors (the medullary zone), niche cells that regulate the choice between progenitor quiescence and hemocyte differentiation [the posterior signaling center (PSC)], and mature blood cells of distinct lineage...

Insect hemocytes mediate important cellular immune responses including phagocytosis and encapsulation and also secrete immune factors such as opsonins, melanization factors, and antimicrobial peptides. However, the molecular composition of these important immune cells has not been elucidated in depth, because of their scarcity in the circulating hemolymph, their adhesion to multiple tissues and...

Serotonin (5-HT) modulates both neural and immune responses in vertebrates, but its role in insect immunity remains uncertain. We report that hemocytes in the caterpillar, Pieris rapae are able to synthesize 5-HT following activation by lipopolysaccharide. The inhibition of a serotonin-generating enzyme with either pharmacological blockade or RNAi knock-down impaired hemocyte phagocytosis. Bioc...

AIM/BACKGROUND Previous studies have suggested that healthy subjects of African ancestry have lower total white cell counts, neutrophil counts and platelet counts than Caucasian subjects and that, at least among Caucasians, women have higher neutrophil and platelet counts than men. The primary aim of this study was to confirm and quantify the ethnic differences, confirm the sex difference in Ca...

OBJECTIVES The study purpose was to determine the optimal use of lumbar puncture (LP) red blood cell (RBC) counts to identify subarachnoid hemorrhage (SAH) when some blood remains in the final tube. METHODS A case series was performed at a tertiary emergency department (ED). Records of 4,496 consecutive adult patients billed for LPs between 2001 and 2009 were reviewed. Inclusion criteria were...

In the present study, a series of five members heterocyclic where synthesized by the reaction between isoniazid and various substituted isothiocyanates. The newly synthesized compounds where characterized by IR and 1H-NMR spectral data. The effect of Thiadiazole derivative (2b) in monocyte and Lymphocyte in the differential count is 20349 and 11415 cells/cu.mm, respectively. Prepared compounds ...

objective(s):gemifloxacin is a broad spectrum antibiotic and has shown excellent coverage against a wide variety of microorganisms. in this study, an attempt was made to evaluate the immunomodulatory potential of gemifloxacin in male swiss albino mice in vivo. materials and methods: three doses of gemifloxacin 25 mg/kg, 50 mg/kg and 75 mg/kg were used intraperitoneally (ip) for the evaluation o...