The survival of species depends on the fertility organisms. It is also worthwhile to study proteins that can regulate reproductive activity Since biological experiments are laborious confirm proteins, it has become a priority develop relevant computational models predict function fertility-related proteins. With development machine learning, pertinent various algorithms be key identifying In th...

We present the structures, bonding characteristics, and infrared spectra of the gold surface (111)−Arg-Cys (Arg-Cys@Au(111)) complex calculated by a periodic plane wave DFT technique. We examine the detailed features of bonding between the gold surface and dipeptide. The dipeptide is revealed to form a covalent bond via the −SH group with 2−3 gold atoms, and also weak noncovalent interactions v...

A lysine auxotroph of Escherichia coli W can use lysine oligopeptides as a source of the required amino acid. A mutant, defective in oligopeptide transport, was isolated from this strain with the use of resistance to the bactericidal action of triornithine as a selection procedure. The triornithine-resistant mutant could no longer grow upon lysine oligopeptides. In an analogous manner a triorni...

A series of amino acid and dipeptide prodrugs of IMB-070593, a fluoroquinolone candidate discovered in our lab, were synthesized and evaluated for their water solubility and then antibacterial activity. Our results reveal that four amino acid prodrugs 4a,b,e,f and two dipeptide prodrugs 4k,l have much greater solubility (>85 mg/mL) than IMB-070593 mesylate (22.5 mg/mL). Compounds 4a and 4k show...