Mitogenic activities on confluent fibroblasts by sera from patients with scleroderma and normal controls were studied. In experiments using eight different fibroblast strains (one human fetal lung fibroblast, one foreskin fibroblast, three adult skin fibroblast, and three scleroderma fibroblast), pooled scleroderma serum showed lower mitogenic activity by 3H-thymidine incorporation assay than p...

BACKGROUND Diffuse coronary atherosclerosis is the substrate for plaque rupture and coronary events. Therefore, in patients with mild arteriographic coronary artery disease without significant segmental dipyridamole-induced myocardial perfusion defects, we tested the hypothesis that fluid dynamically significant diffuse coronary artery narrowing is frequently manifest as a graded, longitudinal,...

T he use of vasodilator thallium-201 myocardial imaging, although still investigational, is finding wide application. The principle of vasodilator thallium-201 myocar-dial imaging was first put forward by Strauss and Pitt,' who used dimethyladenosine in dogs with experimental coronary artery narrowing. They demonstrated that dimethyladenosine increased coronary blood flow and thallium-201 uptak...

Abstract Funding Acknowledgements Type of funding sources: None. Objectives This study aims to assess the role feature-tracking (FT) strain in long-term risk stratification a large population patients with known or suspected coronary artery disease (CAD) undergoing stress cardiac magnetic resonance (S-CMR) dipyridamole. Background Recently, FT has been applied S-CMR improve CAD. However, no dat...

Infusion of dipyridamole has been suggested as an alternative to exercise stress for myocardial perfusion imaging for detection of ischemia, but the mechanism and significance of thallium-201 (201T1) redistribution after administration of dipyridamole are uncertain. If disparate intrinsic cellular efflux rates of 201TI from normal and relatively underperfused myocardium in response to dipyridam...

The role of vasodilators in reducing the extent of myocardial necrosis after acute coronary occlusion has been controversial. The present study was performed to evaluate the efficacy of dipyridamole in reducing infarct size either 8 or 24 hours after ligation of the left anterior descending (LAD) coronary artery in 12 dogs. On the basis of identical epicardial ST-segment elevations 15 minutes a...

BACKGROUND Results of trials of aspirin and dipyridamole combined versus aspirin alone for the secondary prevention of vascular events after ischaemic stroke of presumed arterial origin are inconsistent. Our aim was to resolve this uncertainty. METHODS We did a randomised controlled trial in which we assigned patients to aspirin (30-325 mg daily) with (n=1363) or without (n=1376) dipyridamole...

Background Exogenous adenosine has been shown to increase muscle sympathetic nerve activity (MSNA), blood pressure, heart rate, and ventilation in conscious humans, effects attributed to peripheral chemoreceptor activation. Methods and Results To determine whether endogenous adenosine has similar effects and whether they are mediated through chemoreceptor activation, we examined the effects of ...