Introduction: Pancreatic β-cells are programmed to adapt to elevated levels of glucose by increasing their insulin secretory function. The molecular mechanisms of this process are not fully understood. Peroxisome proliferator-activated receptor-delta (PPAR-delta), which has been shown to play essential roles in regulation of lipid and carbohydrate metabolism, has also been found to function as ...

The differential reflection phase shift, Delta = delta(p) - delta(s), associated with the external reflection of monochromatic light at the surface of an absorbing medium is a monotonically decreasing function of the angle of incidence ø which is determined by the complex dielectric function epsilon. A new special angle of incidence, denoted by ø(Delta'max), is defined at which the slope Delta'...

The objective of this paper is to investigate the accuracy of WinSmash delta-V estimates as a function of crash mode, vehicle body type, and vehicle stiffness. The accuracy of WinSmash delta-V estimates was evaluated for 121 NASS/CDS 2000-2003 cases for which direct measurements of delta-V had been retrieved from an Event Data Recorder on the case vehicle. WinSmash was found to underestimate de...

The function and structure of the TCR proteins of intraepithelial lymphocytes (IEL) were examined using a panel of mAbs specific for TCR-gamma/delta. Three subsets of TCR-gamma/delta+ IEL could be detected with five mAbs, termed GL1-GL5. The mAbs were able to trigger lysis via crosslinking of the IEL TCR and all of the subsets were constitutively cytolytic. Immunoprecipitation of IEL TCR protei...

An efficient means for constructing a narrow bandpass filter for an analogto-digital converter based on a bandpass sigma-delta modulator is presented. It is shown that the filter can be made with very simple hardware, comparable to that required by an analog-to-digital converter using standard lowpass sigma-delta modulation. Introduction Bandpass sigma-delta modulation [1] is a variant of the m...

The function of the minor subset of T lymphocytes bearing the gamma delta T cell antigen receptor is uncertain. Although some gamma delta T cells react to microbial products, responsiveness has only rarely been demonstrated toward a bacterial antigen from a naturally occurring human infection. Synovial fluid lymphocytes from patients with Lyme arthritis contain a large proportion of gamma delta...

Delta and Notch function are required for cell fate specification in numerous tissues during embryonic and postembryonic Drosophila development. Delta is expressed by all members of interacting cell populations within which fates are being specified and is subsequently down-regulated as cells stably adopt particular fates. Multiphasic expression in the derivatives of many germ layers implies su...

The main purpose of this article is to offer some characterizations of $delta$-double derivations on rings and algebras. To reach this goal, we prove the following theorem:Let $n > 1$ be an integer and let $mathcal{R}$ be an $n!$-torsion free ring with the identity element $1$. Suppose that there exist two additive mappings $d,delta:Rto R$ such that $$d(x^n) =Sigma^n_{j=1} x^{n-j}d(x)x^{j-1}+Si...

Voltage-gated calcium channels are thought to exist in the plasma membrane as heteromeric proteins, in which the alpha1 subunit is associated with two auxiliary subunits, the intracellular beta subunit and the alpha(2)delta subunit; both of these subunits influence the trafficking and properties of Ca(V)1 and Ca(V)2 channels. The alpha(2)delta subunits have been described as type I transmembran...

BACKGROUND Oxidative stress, as measured by 8-iso-prostaglandin F(2)(alpha) (8-iso-PGF(2)(alpha)), and depleted antioxidant defenses were shown in stable cystic fibrosis (CF) patients. The plasma fatty acid status of CF patients was linked to oxidative stress after respiratory exacerbations. OBJECTIVE We examined changes in plasma 8-iso-PGF(2)(alpha), antioxidant defenses, plasma fatty acid s...