introduction. this is quasi experimental research in order to determine and compare the learning level of nursing skills ( in b.a students) with self-directed learning and tutor-directed learning pattern in shaheed beheshti univeristy of medical sciences and health services, nursing and midwifery faculty, 1998-1999. methods. first of all, a questionnaire composed of some demographic data such a...

GEO is a well-differentiated colon cancer cell line that coexpresses the epidermal growth factor-like growth factors CRIPTO (CR), amphiregulin (AR), and transforming growth factor alpha (TGF-alpha). Antisense 20-mer phosphorothioate oligodeoxynucleotides (AS S-oligos) directed against CR, AR, and TGF-alpha mRNAs were equipotent in their ability to inhibit both the anchorage-dependent growth and...

Objective: Since colposcopy biopsy test plays a significant role in the evaluation of cervix, especially in patients with an abnormal result of Pap smear test, therefore, this research study was conducted to compare the results of Pap smear and colposcopy directed punch biopsy tests at Firoozgar and Akbarabady hospitals from 2001 to 2003. Materials and Methods: This cross-sectional study was ca...

Zinc (Zn2+) inhibition of N-methyl-D-aspartate receptor (NMDAR) activity involves both voltage-independent and voltage-dependent components. Recombinant NR1/NR2A and NR1/NR2B receptors exhibit similar voltage-dependent block, but voltage-independent Zn2+ inhibition occurs with much higher affinity for NR1/NR2A than NR1/NR2B receptors (nanomolar versus micromolar IC50, respectively). Here, we sh...

A subset $S$ of vertex set $V(D)$ is an {em indpendent dominating set} of $D$ if $S$ is both an independent and a dominating set of $D$. The {em indpendent domination number}, $i(D)$ is the cardinality of the smallest independent dominating set of $D$. In this paper we calculate the independent domination number of the { em cartesian product} of two {em directed paths} $P_m$ and $P_n$ for arbi...

Due to the complex pathogenesis of AD, multitarget-directed ligands (MTDLs) strategy presented best pharmacological option for AD treatment. Herein, a series novel 2-acetylphenol-O-alkylhydroxyethylamine derivatives (5a–f and 6a–f) was rationally designed synthesized. Of these derivatives, 5c good multifunctional agent (eeAChE IC50 = 7.9 μM, MAO-B 9.9 BACE1 8.3 μM) in vitro displayed mixed-type...

Abstract Background The involvement of specific basal ganglia-thalamocortical circuits in response inhibition has been extensively mapped animal models. However, the pivotal nodes and directed casual regulation within this inhibitory circuit humans remains controversial. Methods Here, we capitalize on recent progress robust biologically plausible causal modelling (DCM-PEB) a large dataset (n=25...