occurrence of cutaneous metastasis of gastrointestinal cancer is uncommon, with a reported frequency of less than 5 percent.they can occur as the first sign of disease recurrence in a treated patient or as a sign of terminal disseminated cancer or rarely as the first manifestation of an occult malignancy. the cases reported here represent three different manifestation of cutaneous metastasis of...

tyrosinemia type ii is a rare autosomal recessive disorder wich can present itself with recurrent epithelial keratitis, hyperkeratotic skin lesions and mental retardation. this article reports the rare occurrence of this disease in both offsprings (two brothers) of a family (consanguinous'marriage) who were managed with a lowprotein diet and a special regimen.