Abstract Blue Growth is gaining momentum, opening up new frontiers for economic development, with potentially negative impacts on coastal communities and seascapes. The impact of projects seascapes generally understood through narrow technical or approaches that focus the potential loss views depreciating property values, ignoring complex relationships have These often dislodge non-quantifiable...

Ribosome protection proteins (RPPs) confer resistance to tetracycline by binding to the ribosome and chasing the drug from its binding site. Current models for RPP action are derived from 7.2- to 16-Å resolution structures of RPPs bound to vacant or nontranslating ribosomes. Here we present a cryo-electron microscopy reconstruction of the RPP TetM in complex with a translating ribosome at 3.9-Å...

Mammalian molluscivores feed mainly by shell-crushing or suction-feeding. The extinct marine arctoid, Kolponomos, has been interpreted as an otter-like shell-crusher based on similar dentitions. However, neither the masticatory biomechanics of the shell-crushing adaptation nor the way Kolponomos may have captured hard-shelled prey have been tested. Based on mandibular symphyseal morphology shar...

OBJECTIVE To compare the tensile strength of two approaches for uterosacral ligament suturing using a cadaver model. METHODS In 12 unembalmed cadavers, four polytetrafluoroethylene sutures were placed through the uterosacral ligaments. In each cadaver, two sutures were placed laparoscopically, and two more were placed vaginally. A single, experienced surgeon placed all laparoscopic sutures (n...

Sub-inhibitory concentrations (sub-MIC) of antibiotics play a very important role in selection and development of resistances. Unlike Escherichia coli, Vibrio cholerae induces its SOS response in presence of sub-MIC aminoglycosides. A role for oxidized guanine residues was observed, but the mechanisms of this induction remained unclear. To select for V. cholerae mutants that do not induce low a...

CHEST,VOL.62, NO. 3, SEPTEMBER, 1972 lower lobe pulmonary vein into the left atrium, the catheter became trapped and looped at the level of the atrial septal defect; injection of contrast material revealed its tip to be floating free]y in the left atrium (Fig 1). Attempts at extrication involved the use of guide wires in ax,effort to straighten the catheter, pressure injections of saline soluti...

PURPOSE The purpose of this study was to investigate the dynamic retentive force of a mandibular unilateral distal-extension partial denture framework with a back-action clasp that was designed in a buccally tilted cast on a dental surveyor. The retention mechanism of this framework was analyzed in comparison with other typical unilateral and bilateral frameworks for the mandibular Kennedy clas...

Cell migration is an essential step in cancer invasion and metastasis. A number of orchestrated cellular events involving tyrosine kinases and signaling receptors enable cancer cells to dislodge from primary tumors and colonize elsewhere in the body. For example, activation of the Src and Abl kinases can mediate events that promote tumor cell migration. Also, activation of the Robo1 receptor ca...

AIM The aim of this in vitro study was to compare the change in the retentive force and removal torque of three attachment systems during simulation of insertion-removal cycles. METHODOLOGY Edentulous mandibular models were made with heat-cured polymethyl methacrylate resin. Two implant replicas (CMI), of 3.75 mm diameter and 10 mm length, were placed in the intraforaminal region. Acrylic res...

Protein-disulfide isomerase (PDI) has been proposed to exhibit an "unfoldase" activity against the catalytic A1 subunit of cholera toxin (CT). Unfolding of the CTA1 subunit is thought to displace it from the CT holotoxin and to prepare it for translocation to the cytosol. To date, the unfoldase activity of PDI has not been demonstrated for any substrate other than CTA1. An alternative explanati...