Prader-Willi syndrome (PWS) is an imprinted genetic disorder conferred by loss of paternal gene expression from chromosome 15q11.2-q13. Individuals with PWS have impairments in ventilatory control and are predisposed toward sleep disordered breathing due to a combination of characteristic craniofacial features, obesity, hypotonia, and hypothalamic dysfunction. Children with PWS progress from fa...

1. Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middleaged adults. N Engl J Med. 1993;328:1230--5, http://dx.doi.org/ 10.1056/NEJM199304293281704. 2. Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, et al. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med. 2001;163 3 Pt ...

OBJECTIVE To examine the association between sleep disordered breathing severity and resting energy expenditure (REE). DESIGN Cross-sectional. SETTING University-based academic medical center. PARTICIPANTS Two hundred twelve adults with signs or symptoms of sleep disordered breathing underwent medical history, physical examination, level I attended polysomnography, and determination of RE...

BACKGROUND Sleep-disordered breathing in general and obstructive sleep apnea in particular are commonly encountered conditions in allergy practice. Physiologically, nasal (or nasopharyngeal) obstruction from rhinitis, nasal polyposis, or adenotonsillar hypertrophy are credible contributors to snoring and nocturnal respiratory obstructive events. Nevertheless, existing practice parameters largel...

OBJECTIVES To determine the prevalence of sleep-disordered breathing in children with sickle cell disease and whether there is an association of sleep-disordered breathing with high-risk transcranial Doppler ultrasonography (TCD) velocities. Study DESIGN Cross-sectional. SETTING Tertiary care academic medical center. PATIENTS Sixty-four children (aged 2-14 years) selected for eligible gen...

RATIONALE Although research supports a sleep-disordered breathing and atrial fibrillation association, prospective data examining sleep-disordered breathing predicting incident atrial fibrillation are lacking. OBJECTIVES To investigate sleep-disordered breathing indices as predictors of incident atrial fibrillation. METHODS A cohort (n = 843) of ambulatory older men without prevalent atrial...

STUDY OBJECTIVE This study was designed to determine whether different desaturation indexes (DIs) would be obtained in patients with sleep-disordered breathing by systematically altering two acquisition parameters: the recording setting and the display mode. DESIGN Prospective clinical study. SETTING Community sleep-disorders center. PATIENTS The study included 75 patients who were suspec...

STUDY OBJECTIVES The functional somatic syndromes are associated with a variety of symptoms/signs of uncertain etiology. We determined the prevalence of several of those symptoms/signs in patients with sleep-disordered breathing and examined the relationship between the prevalence of the symptoms/signs and the severity of sleep-disordered breathing. DESIGN A descriptive study without interven...