Studies on the kinetics of dissolution of a Nigerian lateritic soil in acids media including hydrochloric, nitric and sulphuric acids have been undertaken. The elemental and mineralogical characterization, loss of mass on ignition, moisture content and pH of the material suspension in water were determined. The effects of acid concentration, process temperature, stirring rate and particle size ...

To quantify the relationships between buffering properties and acid erosion and hence improve models of erosive potential of acidic drinks, a pH-stat was used to measure the rate of enamel dissolution in solutions of citric, malic and lactic acids, with pH 2.4-3.6 and with acid concentrations adjusted to give buffer capacities (β) of 2-40 (mmol·l(-1))·pH(-1) for each pH. The corresponding undis...

The majority of drugs have a low dissolution rate, which is a limiting step for their absorption. In this manuscript, solid dispersions (SD), solid self-microemulsifying drug delivery systems (S-SMEDDS) and solid self-nanoemulsifying drug delivery systems (S-SNEDDS) were evaluated as potential formulation strategies to increase the dissolution rate of carbamazepine. Influence of increased disso...

Hydroxyapatite (HAp) and β-tricalcium phosphate (β-TCP) are widely used bioceramics for surgical or dental applications. This paper is dealing with dissolution kinetics of synthetically prepared β-TCP and four types of HAp granules. Two groups of HAp, treated at different temperatures, each of them with two different granule sizes, were tested. Three corrosive solutions with different pH and si...

Colemanite is a preferred boron mineral in industry, such as boric acid production, fabrication of heat resistant glass, and cleaning agents. Dissolution of the mineral is one of the most important processes for these industries. In this study, dissolution of colemanite was examined in water saturated with carbon dioxide solutions. Also, prediction of dissolution rate was determined using artif...

Drug absorption in the human body depends on the dissolution rate of the drug. Suitable dissolution characteristics are important to ensure that the drug will achieve the desired therapeutic effects. To assess the similarity of dissolution rates of several drug lots, we apply a general growth curve model with different covariance structures. The Box-Cox power transformation and the naive log tr...

This paper examines the effects of resource complementarity and organizational compatibility on merger and acquisition (M&A) outcomes. We also explore the effect of firms' previous M&A experiences. Our investigation focuses on two classes of events following M&As: organizational dissolution and involvement in subsequent M&As, with the firm continuance following the M&A as the “non-event.” Using...

Film dosage forms (FDs) containing valsartan (VST), a popular antihypertensive drug, were prepared using a casting method with sodium alginate and other polysaccharides as the film base. Drug dissolution profiles of the FDs were investigated in limited medium. The FDs were 170-200 μm thick and were easy to handle. All FDs immediately swelled and disintegrated in the medium. About 23% of the VST...

piroxicam (px), an anti-inflammatory drug, exhibits poor water solubility, dissolution and flow properties. thus, the aim of the present study was to improve the solubility and dissolution rate of px by freeze drying technique using dimethylformamide (dmf), chloroform and water as co-solvent system. the prepared crystals containing px were evaluated for dmf and chloroform solvent residual by ga...

the formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a hydroph...