نتایج جستجو برای: dissolution reprecipitation

تعداد نتایج: 21070  

2013
S. Jaya P. Rajeswara Rao

Ritonavir, a widely prescribed anti-retroviral drug, belongs to Class II under 'BCS' and exhibit low and variable oral bioavailability due to its poor aqueous solubility. Ritonavir is practically insoluble in water and aqueous fluids. Its aqueous solubility was reported to be 2.56 mg/100 ml. As such oral absorption of ritonavir is dissolution rate limited and it requires enhancement in solubili...

Journal: :International braz j urol : official journal of the Brazilian Society of Urology 2013
Maneesh Sinha Kumar Prabhu Prasanna Venkatesh Venkatesh Krishnamoorthy

PURPOSE In this paper we present our experience with dissolution therapy of radiolucent calculi. MATERIALS AND METHODS This was a retrospective analysis of patients who were offered urinary dissolution therapy between January 2010 and June 2011. Patients were treated with tablets containing potassium citrate and magnesium oxide. Partial dissolution was defined as at least a 50% reduction in s...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2017
Adam V Subhas Jess F Adkins Nick E Rollins John Naviaux Jonathan Erez William M Berelson

Near-equilibrium calcite dissolution in seawater contributes significantly to the regulation of atmospheric [Formula: see text] on 1,000-y timescales. Despite many studies on far-from-equilibrium dissolution, little is known about the detailed mechanisms responsible for calcite dissolution in seawater. In this paper, we dissolve 13C-labeled calcites in natural seawater. We show that the time-ev...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2005
Patricia M Dove Nizhou Han James J De Yoreo

The central control of mineral weathering rates on biogeochemical systems has motivated studies of dissolution for more than 50 years. A complete physical picture that explains widely observed variations in dissolution behavior is lacking, and some data show apparent serious inconsistencies that cannot be explained by the largely empirical kinetic "laws." Here, we show that mineral dissolution ...

2014
Andrew L. Fussell Peter Kleinebudde Jennifer Herek Clare J. Strachan Herman L. Offerhaus

Traditional pharmaceutical dissolution tests determine the amount of drug dissolved over time by measuring drug content in the dissolution medium. This method provides little direct information about what is happening on the surface of the dissolving tablet. As the tablet surface composition and structure can change during dissolution, it is essential to monitor it during dissolution testing. I...

Journal: :Acta pharmaceutica 2017
Oluchi N Mbamalu James Syce Halima Samsodien

Unlike the case of conventional drug formulations, dissolution tests have hitherto not been required for herbal medicinal products commercially available in South Africa. This study investigated dissolution of the South African Sutherlandia frutescens using selected flavonoid glycosides as marker compounds. Dissolution of markers was assessed in three dissolution media at pH 1.2, 4.5 and 6.8, a...

Journal: :iranian journal of pharmaceutical research 0
malihe shahbaziniaz 1- department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. 2- student research committee, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. seyed mohsen foroutan department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran. noushin bolourchian department of pharmaceutics, school of pharmacy, shahid beheshti university of medical sciences, tehran, iran.

clarithromycin (cla), a broad-spectrum macrolide, is a poorly soluble drug with dissolution rate limited absorption. the aim of this investigation was to prepare cla nanoparticles from a ternary ground mixture in the presence of sodium lauryl sulfate (sls) and polyvinyl pyrrolidone (pvp) as co-grinding water-soluble compounds, in order to improve the drug dissolution rate. different weight rati...

2010
E. Ufkes D. Kroon

Here we study the carbonate dissolution history of the deep SE Atlantic as evidenced in proxy records in Core T89-40 from the Walvis Ridge, spanning the last 1.1 million years. All dissolution proxy records (fragmentation index, ratio of planktonic and benthic foraminifera, sand fraction and number of planktonic foraminifera per gram sediment) show similar patterns, unique events, and these pro...

2016
Ragna Berthelsen René Holm Jette Jacobsen Jakob Kristensen Bertil Abrahamsson Anette Müllertz

This study describes various complications related to sample preparation (filtration) during development of a dissolution method intended to discriminate among different fenofibrate immediate-release formulations. Several dissolution apparatus and sample preparation techniques were tested. The flow-through cell apparatus (USP 4) was found unfit for dissolution testing of fenofibrate MeltDose fo...

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