The objective of present study was to develop and validate a dissolution test for polyherbal hepatoprotective tablets containing andrographolide with bio-relevant media. Different dissolution conditions such as basket (type I)/paddle (type II) agitation, rotation speed, dissolution medium and volume were evaluated. The dissolution samples were analyzed and validated using a high-performance liq...

The aim of present study was to prepare and characterize the recrystallized agglomerates of water insoluble non steroidal anti-inflammatory drug, indomethacin (IM) with hydrophilic polymers like polyvinyl pyrrolidone (PVP),hydroxyl ethyl cellulose (HEC) and hydroxyl propyl methyl cellulose (HPMC) by using emulsion solvent diffusion (ESD) technique for enhancing the solubility, dissolution rate,...

OBJECTIVES This study aimed to evaluate the capacity of 2% chlorhexidine gel associated with 8% papain gel in comparison with 5.25% sodium hypochlorite in bovine pulp tissue dissolution. MATERIALS AND METHODS Ninety bovine pulps of standardized sizes were used and fragmented into 5-mm sizes. The fragments were removed from the root middle third region. They were divided into 6 experimental gr...

Purpose: To enhance the solubility and dissolution characteristics of ketoprofen using various crystallization techniques. Methods: Ketoprofen crystals were prepared by various crystallization technique including spherical agglomeration (SA), spray drying (SD), freeze drying (FD) and super cooling (SC). The crystallization medium used for all the techniques consisted of water and chloroform. Re...

The main purpose of this research was to study the mechanism of drug release from solid dispersions of albendazole, giving special emphasis to particle size of the drug in solid dispersions. Solid dispersions were prepared using three different carriers, mixing ratios and methods in an attempt to improve the solubility and dissolution rate of albendazole. The mechanism of enhanced dissolution w...

The study objectives were to assess the ability of intratracheal injection methods to discriminate between nine ®bre types in respect of pulmonary biopersistence, and to provide approximate estimates of relative biopersistence and durability for a study of general relationships with biological and toxicological responses. The test ®bres included six samples of size-selected ®bre types specially...

The bioequivalence of three chemically equivalent paracetamol generic Mexican products (500 mg tablets) was evaluated in 12 healthy volunteers using the American innovator product (Tylenol, McNeil, Fort Washington, PA), as the reference. Single oral doses of each product were administered at 1-week intervals using a 4 x 4 Latin square design balanced for the first residual effect. The total amo...

This in vitro study evaluated (1) the dissolution of bovine pulp tissue in solutions consisting of varying NaOCl concentrations and combined with EDTA; and (2) the pH of these solutions before and after the experiment. The independent variables were the concentration and the volume of the solution. Thirty bovine pulps were divided in equal fragments, resulting in 90 fragments of pulp tissue. Ea...

Introduction Drug dissolution testing is an integral part of drug product development and quality assessment. Often drug dissolution testing is a regulatory requirement to establish the quality of a drug product [1-3]. In reality,drug dissolution testing is a solubility determination technique. It utilizes specialized equipment for that purpose,commonly known as basket and paddle apparatuses. T...

The present study investigates the possibility of using poloxamers as solubility and dissolution rate enhancing agents of poorly water soluble bioactive constituent patchouli alcohol (PA) that can be used for the preparation of immediate release pellets formulation. Two commercially available grades poloxamer 188 (P 188) and poloxamer 407 (P 407) were selected, and solid dispersions (SDs) conta...