ATP/dithiothreitol (DTT)-stimulated guanylate cyclase (GC) in lung membrane was stimulated 18-fold by ATP and DTT, and both its activity and atrial natriuretic peptide (ANP)-stimulated GC activity were observed to be additive. ATP/DTT-stimulated GC was solubilized by octyl glucoside (OG) to examine the mechanism of ATP/DTT-stimulation. GC in OG-extracts was stimulated maximally 2.5-fold by both...

Cu(I) binding promotes the platination of Atox1, although cisplatin binds to the copper coordination sites. In addition, Cu(I) binding enhances the competition of Atox1 with DTT in the reaction of cisplatin. These results indicate that cuprous ions could regulate the cellular trafficking of cisplatin.

The relative importance of regulation at the mRNA versus protein level is subject to ongoing debate. To address this question in a dynamic system, we mapped proteomic and transcriptomic changes in mammalian cells responding to stress induced by dithiothreitol over 30 h. Specifically, we estimated the kinetic parameters for the synthesis and degradation of RNA and proteins, and deconvoluted the ...

This paper describes how experimentally detected Majorana-particles fit a new cosmological theory. This theory is called the rotating Double Torus Theory (DTT). It is extensively described by a cascade of articles, which are published in the vixra-archive by the author. However, although Majorana-particles will contribute very likely to the development of stable quantumcomputers in the near fut...

Abstract Background This study aimed to evaluate the effects of different pretreatment methods on microbial yield from infectious tissues. Methods Strains Staphylococcus aureus (SA), Escherichia coli (EC) and Candida albicans (CA) were used construct single-surface, full-surface, internal infection models in sterile pork tissue. Manual milling (MM), mechanical homogenization (MH), sonificated (...