objective(s):oct4 is a transcription factor required for pluripotency during early embryogenesis and the maintenance of identity of embryonic stem cells and pluripotent cells. therefore, the effective expression regulation of this gene is highly critical. utr regions are of great significance to gene regulation. in this study, we aimed to investigate the potential regulatory role played by 5´ut...

In recent years, natural antisense transcripts (NATs) have been implicated in many aspects of eukaryotic gene expression including genomic imprinting, RNA interference, translational regulation, alternative splicing, X-inactivation and RNA editing. Moreover, there is growing evidence to suggest that antisense transcription might have a key role in a range of human diseases. Consequently, there ...

background: myelodysplastic syndromes (mdss) include a diverse group of clonal bone marrow disorders characterized by ineffective hematopoiesis and pancytopenia.it was found that down regulation of apaf1, a putative tumor suppressor gene (tsg),leads to resistance to chemotherapy and disease development in some cancers. in this study, we investigated the relation of apaf1 methylation status with...

Background and Aims: TGF-β is an effective cytokine in the viral replication cycle, which is also highly relevant to the pathogenesis of some viral infections. TGF-β induction by viral proteins is one of the ways to escape the virus from the immune system by inhibiting interferon signaling and other immune system factors.  In recent years, the role of TGF-β and its inhibitor...

Gnostic prose works cover a wide range of subjects, contents, styles, structures, languages, and manners of expression. They might, therefore, be all categorized under one single literary genre. Applying the general term "gnostic prose works" to these oeuvres hinders our understanding of their true nature. Despite that many gnostic prose works belong to Gnosticism, they have special characteris...

poetic inspiration is one of the major topics dealt with in literary criticism. the objective of this paper is to show the similarities between human birth and composition of poetry , which as qabbani requires a lot of care to be taken so as to protect the child the against

Background and Objective: Recent studies have shown that not only the quantity, but also the quality of dietary fatty acids can affect lipid parameters. Elaidic acid is a major hydrogenated by-product of vegetable oil play a role in the development of cardiovascular disease, especially atherosclerosis, through changing lipid profile and increase in inflammation and inflammatory factors. On the ...