Diabetic nephropathy (DN) is the leading cause of end-stage renal disease. The use of experimental models of DN has provided valuable information regarding many aspects of DN, including pathophysiology, progression, implicated genes, and new therapeutic strategies. A large number of mouse models of diabetes have been identified and their kidney disease was characterized to various degrees. Most...

Suppressor of cytokine signaling 2 (SOCS2) was reported to be involved in the development of Diabetic Nephropathy (DN). However, its underlying mechanism remains undefined. Western blot was carried out to determine the expressions of SOCS2, Toll-like receptors 4 (TLR4) and nuclear factor kappa B (NF-κB) pathway-related proteins in DN patients, streptozotocin (STZ)-induced DN rats and high gluco...

Double network (DN) gels, consisting of a brittle first and flexible second network, have been known to be extremely tough and functional hydrogels. In a DN gel subjected to force, the brittle first network breaks prior to the fracture of the flexible network. This process, referred to as internal fracture, dissipates energy and increases the energy required to completely fracture DN gels. Such...

Diabetic nephropathy (DN) is the leading cause of end-stage kidney disease worldwide but current treatments remain suboptimal. The role of inflammation in DN has only recently been recognized. It has been shown that the NLRP3-inflammasome contributes to DN development by inducing interleukin (IL)-1β processing and secretion. In an effort to understand other IL-1β activating mechanism during DN ...

BACKGROUND Atrial natriuretic peptide is involved in blood pressure regulation via its vasodilating and natriuretic actions. Since diabetic nephropathy and hypertension are closely related, ANP is a reasonable candidate gene for diabetic nephropathy (DN). METHODS We genotyped 410 patients with type I diabetes (without DN n = 307; with DN n = 103) and 658 patients with type II diabetes (withou...

BACKGROUND Dioscoreanone (DN) isolated from Dioscorea membranacea Pierre has been reported to exert potent cytotoxic effects against particular types of cancer. The present study was carried out to investigate the cytotoxicity of DN against a panel of different human lung cancer cell lines. The study further examined the underlying mechanisms of its anticancer activity in the human lung adenoca...

OBJECTIVES Describe the incidence, prevalence and survival of patients needing renal replacement therapy (RRT) for end-stage renal disease (ESRD) due to diabetes mellitus (DM)-related glomerulosclerosis or nephropathy (diabetic nephropathy, DN) in the Netherlands. DESIGN Using the national registry for RRT (RENINE-registry), data of all Dutch individuals initiating RRT for ESRD and having DN ...

Aims Natural N abundance provides integrated information about nitrogen (N) input, transformation and output, indirectly reflecting N cycling traits within terrestrial ecosystems. However, relationships between natural N abundance and N cycling processes are poorly understood in China. Here, our primary objectives were to (i) examine the effects of grazing at varying levels of intensity on dN o...

BACKGROUND The most striking abnormality in the renin angiotensin system in diabetic nephropathy (DN) is increased plasma prorenin. Renin is thought to be low or normal in DN. In spite of altered (pro)renin regulation the renin gene has not been studied for contribution to the development of DN. METHODS We studied plasma renin, prorenin, and four polymorphic markers of the renin gene in 199 p...

Exosomes, a major type of extracellular vesicles (EVs), are nanoscale excreted by almost all cell types via invagination the endosomal membrane pathway. Exosomes play crucial role in mediation intercellular communication both health and disease, which can be ascribed to their capacity transported neighboring or distant cells, thus regulating biological function recipient cells through cargos su...