Mutation of a small number of amino acids in the DNA-binding domain of the estrogen receptor to the corresponding sequence of the glucocorticoid receptor switches the specificity of the receptor in transactivation assays (Mader, S., Kumar, V., de Verneuil, H., and Chambon, P. (1989) Nature 338, 271-274). We have made the corresponding reciprocal mutations in the context of the glucocorticoid re...

trichophyton rubrum (t. rubrum) is an anthropophilic dermatophyte that is distributed worldwide and causes common cutaneous disease such as mycosis. although several properties of this fungus have been investigated so far, however a few studies were carried out in the field of molecular biology of this fungus. in the present study we tried to identify its molecular characterization of the goano...

A comparison between two truncated DNA aptamers reported to bind with cortisol was performed and binding observed only for one of them. Two label-free sensing methods were studied including cortisol/gold nanoparticle interactions critical colorimetric sensing.

mechanism of the binding of lomefloxacin (lmf) with human serum albumin has been studied at physiological ph (7.4) using fluorescence spectroscopic technique. lmf is a third-generation fluoroquinolone antibiotic that exhibits striking potency against a broad spectrum of gram-negative and gram-positive bacteria through inhibition of dna gyrase. lomefloxacin is a drug that is excreted in urine an...

Colonization of nontypeable Haemophilus influenzae (NTHi) in nasopharynx causes respiratory tract disease. In 80% of clinical isolates, HMW proteins are the major adhesions and induce protective antibodies in the hosts. Therefore, it can be used as a vaccine candidate. The aim of this study is designing and cloning of the conserved regions of NTHi hmw1 core binding domain.In this study, the sta...