نتایج جستجو برای: dna radioprotection

تعداد نتایج: 507977  

Journal: :European journal of endocrinology 2002
Olga Madrid Silvia Varea Isabel Sanchez-Perez Lourdes Gomez-Garcia Enrique De Miguel Ignacio A Gomez De Segura Rosario Perona

BACKGROUND In vivo treatment with growth hormone reduces radiation-associated mortality. The molecular mechanisms underlying this effect are unknown. It has been described that increased sensitivity to ionising radiation can be due to defects in machinery involved in detection and/or repair of DNA double-strand breaks. OBJECTIVE To study the mechanisms involved in growth hormone action on the...

2006
Geraldine D. Smoluk Robert C. Fahey Paula M. Calabro-Jones Joseph A. Aguilera John F. Ward

Studies of V79-171 cells were undertaken to determine what extracel lular or intracellular derivative of the drug WR-2721 is associated with radioprotection. The effect of preincubation at 23 ±1°Cwith WR-2721, and with derivatives of WR-2721 produced in medium containing alkaline phosphatase, upon survival of cells following subsequent -y-irradiation was examined. It was established that WR-2...

Journal: :Journal of radiation research 2007
Dani Mathew Cherupally Krishnan K Nair Jasmin A Jacob Nandita Biswas Tulsi Mukherjee Sudhir Kapoor Tsutomu V Kagiya

Ascorbic acid monoglucoside (AsAG), a glucoside derivative of ascorbic acid, has been examined for its antioxidant and radioprotective abilities. AsAG neutralized 1, 1 diphenyl -2-picryl-hydrazyl (DPPH), a stable free radical in a concentration dependent manner thus indicating its antioxidant ability. AsAG protected mice liver tissues in vitro from peroxidative damage in lipids (measured as TBA...

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