Most state-of-the-art protein-protein docking algorithms use the Fast Fourier Transform (FFT) technique to sample the six-dimensional translational and rotational space. Scoring functions including shape complementarity, electrostatics, and desolvation are usually exploited in ranking the docking conformations. While these rigid-body docking methods provide good performance in bound docking, us...

Based on the basic problems such as motivation of quality and safety management control agricultural supermarket docking supply chain, this paper studies game behavior three parties involved in professional cooperatives, large chain supermarkets government regulatory departments under influence participation. To build a three-party evolutionary model for with participation government, goal is t...

Macrophage migration inhibitory factor (MIF) is a major proinflammatory cytokine that has been increasingly implicated in the pathogenesis of several inflammatory, autoimmune, infectious and oncogenic diseases. Accumulating evidence suggests that the tautomerase activity of MIF plays a role in modulating some of its intra- and extra-cellular activities. Therefore, the identification and develop...

changes in credit risk may arise when either the value or the risk of corporate assets changes. changes in the equity value associated with the changes in the asset value and changes in asset risk can be characterized into potentially countervailing direct and indirect effects. the indirect effect of risk on equity value is a function of factors that affect the debt value of including leverage,...

Docking to the plasma membrane prepares vesicles for rapid release. Here, we describe a mechanism for dense core vesicle docking in neurons. In Caenorhabditis elegans motor neurons, dense core vesicles dock at the plasma membrane but are excluded from active zones at synapses. We have found that the calcium-activated protein for secretion (CAPS) protein is required for dense core vesicle dockin...

introduction:  stereotactic  radiosurgery  is  a  technique  for  the  treatment  of  intracranial  lesions  with  highly  collimated  x-ray  beam.  linac-based  radiosurgery  is  currently  performed  by  two  techniques:  couch or pedestal mounted. in the first technique, a device is required to affix patient's head to a couch  and  moreover  to  translate  it  accurately.  structure  of...

effects of partial docking on feedlot performance and body fat characteristics were studied in a fat-tailed sheep breed. thirty-eight male lambs with an average weight of 4.44 ± 0.48 were randomly divided into two groups. the lambs in one group were partially docked at 3-4 h after birth, using rubber rings, and the lambs in another group remained intact (control). after weaning, 20 male lambs f...

modeling and simulation techniques are now widely used alongside with their experimental counterparts in order to complement them, or sometimes to bring first insights into the possible outcome of experiments. “modeling” is a general word that could encompass a wide range of methods that could be applied to a variety of subjects and problems. here, the use of selected molecular modeling methods...

the aim of the study was to investigate the effect of tail-docking on the lh pulse frequency in femaletuj lambs. twelve female lambs were assigned into two equal groups. a rubber ring was applied to the baseof the tail for shedding off. blood samples were collected for 8 h in the 4th and 8th months of age todetermine pulsatile secretion of lh. starting from the age of 6 months, blood samples we...