PURPOSE To determine the optimal conditions for enhancing corneal allograft survival by oral immunization with donor-specific alloantigens. METHODS CB6F1 mice were orally immunized with various doses of C3H/Hej corneal epithelial and endothelial cells before receiving orthotopic C3H/Hej corneal allografts. Paraformaldehyde-fixed corneal cells were compared with viable corneal cells for their ...

BACKGROUND AND OBJECTIVES Rapid discontinuation of prednisone after kidney transplantation potentially allows for minimization of steroid-related side effects. Although intermediate-term data with rapid discontinuation of prednisone have been promising, concern still exists regarding long-term outcomes. The 10-year experience is reported herein. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS B...

Recent studies have shown that host-reactive interleukin2 (IL-2)-secreting donor T lymphocytes (TI) are critically involved in the development of acute graft-versus-host disease (GVHD) after allogeneic HLA-identical sibling bone marrow transplantation (BMT). To further characterize the responding TI, we determined the frequency of pretransplant IL-2-secreting TI-precursors (TI-p) between eight ...

Marrow graft failure observed in association with histocompatibility differences between donor and recipient is often attributed to rejection mediated by host-derived cytolytic T lymphocytes. The data presented in this report indicate that persistent host antibodies specific for donor antigen may also mediate graft failure, either by antibody-dependent cell-mediated cytotoxicity (ADCC), or comp...

Although regarded as a gold standard, harvesting of autologous bone graft is associated with donor site morbidity and a number of complications. An alternative is allograft with limited availability as the main shortcoming. Femoral heads as allografts are now routinely obtained during total hip arthroplasty. A small but valuable amount of pure cancellous bone graft of high quality can be obtain...

Transplant physicians and candidates have become increasingly aware that donor characteristics significantly impact liver transplantation outcomes. Although the qualitative effect of individual donor variables are understood, the quantitative risk associated with combinations of characteristics are unclear. Using national data from 1998 to 2002, we developed a quantitative donor risk index. Cox...

There is a paucity of literature examining recipient-donor obesity matching on liver transplantation outcomes. The United Network for Organ Sharing database was queried for first-time recipients of liver transplant whose age was ≥18 between January 2003 and September 2013. Outcomes including patient and graft survival at 30 days, 1 year, and 5 years and overall, liver retransplantation, and len...

Dysregulated donor T cells lead to destruction of host tissues resulting in graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). We investigated the impact of highly purified (>95%) donor CD4(+) invariant natural killer T (iNKT) cells on GVHD in a murine model of allogeneic HCT. We found that low doses of adoptively transferred donor CD4(+) iNKT cells prot...

purpose: to evaluate corneal hysteresis and corneal resistance factor in penetrating keratoplasty grafts in a group of keratoconic eyes using the ocular response analyzer (ora) and to evaluate the relationship between donor size, donor-recipient disparity and central graft thickness (cgt), and ora parameters. methods: this cross-sectional study was conducted on 34 eyes of 34 keratoconus patient...