Adriamycin, a cancerostatic anthracycline antibiotic, causes considerable death of tumour cells, together with the induction of breaks in DNA single and double strands. The interaction of this compound with DNA was investigated using an electrochemical DNA-biosensor. Adriamycin intercalation in DNA disrupts the double helix and the detection of guanine and 8-oxoguanine could mimic one possible ...

Aims: We aimed to compare the effects of anesthesia induction on hemodynamic parameters ketamine-midazolam or etomidate-midazolam combinations and coronary artery bypass grafting surgery.
 Material Methods: 40 adult patients undergoing CABG were randomly allocated into two groups for this prospective randomized double-blinded study. Ketamine group (n = 20) Etomidate 20). Intraoperative pos...

Double-stranded RNA viruses face two major problems: the endogenous machinery of its host cells does not replicate RNA genomes, and double-stranded RNA provokes strong cellular defence responses such as interferon induction and gene silencing. The solution for the virus is to keep the genomic double-stranded RNA always in a separate container, an icosahedral viral capsid, and to more-or-less au...

Let CAn=C[S2?S2???S2] be the group algebra of an n-step iterated wreath product. We prove some structural properties An such as their centers, centralizers, and right double cosets. apply these results to explicitly write down Mackey theorem for groups give a partial description natural transformations between induction restriction functors on representations product tower by computing certain ...

Introduction: Blood loss is a common concern during functional endoscopic sinus surgery (FESS). The present study aimed to evaluate the efficacy of dexmedetomidine (DEX) in intraoperative bleeding and surgical field in FESS.   Materials and Methods: This double-blind randomized clinical trial was conducted on 72 patients within the age range of 16-60 years who underwent ...

Autologous transplantation is controversial for older patients with multiple myeloma. The role of age-adjusted high-dose melphalan and the impact of induction chemotherapy cycles is still unclear. A total of 434 patients aged 60-70 years were randomly assigned to 4 cycles of standard anthracycline-based induction chemotherapy or no induction. For all patients, double autologous transplantation ...

Telomeres, the ends of linear eukaryotic chromosomes, have a specialized chromatin structure that provides a stable chromosomal terminus. In budding yeast Rap1 protein binds to telomeric TG repeat and negatively regulates telomere length. Here we show that binding of multiple Rap1 proteins stimulates DNA double-stranded break (DSB) induction at both telomeric and non-telomeric regions. Consiste...