BACKGROUND Pyridostigmine bromide (3-[[(dimethylamino)-carbonyl]oxy]-1-methylpyridinium bromide), a reversible inhibitor of cholinesterase, is given orally in tablet form, and a treatment schedule of multiple daily doses is recommended for adult patients. Nanotechnology was used in this study to develop an alternative sustained-release delivery system for pyridostigmine, a synthetic drug with h...

Continuous and simultaneous 3D single-particle movement and local pH detection in HeLa cells were demonstrated for the first time by combining fluorescent mesoporous silica nanoparticles (FMSNs) and a single-particle tracking (SPT) technique with a precision of ∼10 nm. FMSNs, synthesized by the co-condensation of both pH-sensitive and reference dyes with a silica/surfactant source, allow long-t...

The present work investigates the coalescence process of two gold nanoparticles for a host of initial temperatures and starting radii in vacuum with the help of molecular dynamics (MD) simulations. Diverse mechanisms of the first sintering stage, characterized by a growing neck region, were found. The results are compared with a phenomenological macroscopic model based on an energy balance and ...

Conduction spectroscopy measures the current I through a nanosystem as a function of the voltage V between two electrodes. The differential conductance, dI/dV, has peaks that can be assigned to resonance conditions with different electronic levels of the system. Between these increments, the current has roughly constant plateaus. We discuss how measurements of the current vs. voltage can be use...

In this study, nonlocal nonlinear instability and the vibration of a double carbon nanotube (CNT) system have been investigated. The Visco-Pasternak model is used to simulate the elastic medium between nanotubes, on which the effect of the spring, shear and damping of the elastic medium is considered. Both of the CNTs convey a viscose fluid and a uniform longitudinal magnetic field is applied t...