Doxorubicin is the chemotherapeutic drug of choice for a wide variety of cancers, and cardiotoxicity is one of the major side effects of doxorubicin treatment. One of the main cellular targets of doxorubicin in the heart is mitochondria. Mitochondrial sirtuin, SIRT3 has been shown to protect against doxorubicin-induced cardiotoxicity. We have recently identified honokiol (HKL) as an activator o...

AIM To compare the molecular profile and cell cycle of sensitive and resistant to doxorubicin MCF-7 breast cancer cells upon exposition to conventional or liposome-encapsulated forms of doxorubicin. METHODS capital EM, Cyrilliccapital TE, Cyrilliccapital TE, Cyrillic-test, immunocytochemistry, flow cytometry. RESULTS In sensitive MCF-7 cells the exposure to conventional but not liposomal fo...

In addition to increasing the efficacy of various drugs, Nanoparticles reduce their side effects. In this study, different nanoparticle formulations of Doxorubicin anticancer drugs were prepared. The efficacy of the formulations produced in the cell culture medium was studied compared with the free drug. Reverse phase evaporation was used to form the liposome containing do...

Doxorubicin is an effective chemotherapeutic drug, however, its toxicity is a significant limitation in therapy. Encapsulation of doxorubicin inside liposomes or ferritin cages decreases cardiotoxicity while maintaining anticancer potency. We synthesized novel apoferritin- and liposome-encapsulated forms of doxorubicin ("Apodox" and "lip-8-dox") and compared its toxicity with doxorubicin and My...

Doxorubicin is a useful antineoplastic drug with multiple mechanisms of cytotoxicity. One such mechanism involves the reductive bioactivation of the quinone ring to a semiquinone radical, which can exert direct toxic effects and/or undergo redox cycling. We hypothesized that human NADPH-cytochrome p450 reductase (CYPRED) catalyzes doxorubicin reduction and that overexpression of this enzyme sen...

BLOOD VESSEL DISEASES Blood vessels have a primary function of nourishing various organs and tissues of the body by supplying them with blood. Vascular diseases are manifested clinically through three mechanisms that are reflected through the diseased vessel (s) as 1. Progressive narrowing of the lumen associated with progressive ischemia of the relevant tissues. 2. Thrombosis associated with p...

Abstract: Background and Objectives: Myocardial ischemia is one of the leading causes deaths among cardiac pathological conditions. Doxorubicin belongs to anthracycline class drug which effective against a wide variety neoplasms. However, doxorubicininduced cardiotoxicity limits clinical utility drug. One major myocardial oxidative stress. Adhatoda vasica have been shown possess strong anti-inf...

single-walled carbon nanotubes (swnts) are among the promising nano-devices for delivery of therapeutic agents. yet the drastic hydrophobic natures of swnts make their handling and hence application difficult.several researches have been conducted to make them more hydrophilic and water dispersible and less toxic. among the different approaches, dispersion methods exploit different reagents suc...

BACKGROUND Doxorubicin is used to treat childhood and adult cancer. Doxorubicin treatment is associated with both acute and chronic cardiotoxicity. The cardiotoxic effects of doxorubicin are cumulative, which limits its chemotherapeutic dose. Free radical generation and p53-dependent apoptosis are thought to contribute to doxorubicin-induced cardiotoxicity. METHODS AND RESULTS Adult transgeni...