Abstract Objectives Endoplasmic reticulum (ER) stress plays a significant role in the progression of diabetic kidney disease (DKD), and dipeptidyl peptidase-4 (DPP4) inhibitors are widely used antihyperglycemic agents, exerting renal beneficial effects DKD. Here, we investigated DPP4 inhibitor Sitagliptin (Sita) ER homeostasis kidneys DBA2/J (D2) mice albumin-stimulated HK-2 cells. Methods Resu...

Abstract Background Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase able to inactivate various oligopeptides, and also hepatokine. Hepatocyte-specific overexpression of DPP4 associated with hepatic insulin resistance liver steatosis. Method We examined whether weekly inhibitor omarigliptin (OMG) can improve function as well levels inflammation in type 2 diabetic patients non-alcoholic fa...

The term incretin effect was used to describe the fact that oral glucose load produces a greater insulin response than that of an isoglycemic intravenous glucose infusion. This difference has been attributed to gastrointestinal peptides GLP-1 and GIP. Since incretin effect is reduced in subjects with type 2 diabetes, despite GLP-1 activity preservation, two forms of incretin-based treatment hav...

A COVID-19 se tornou uma questão de alto risco preocupação global. O pico da glicoproteína (S) no envelope do vírion é clivado proteoliticamente nas subunidades S1 e S2, o reconhecimento receptor mediado pelo domínio ligação ao (RBD) fusão membrana. Trata-se revisão bibliográfica caráter qualitativo que baseia na produção científica a partir estudos já publicados entre os anos 2019 2021 abordav...

Injury to the skin results in establishment of fibrosis, which inversely correlates with capacity for regeneration appendages such as hair follicles (HF). Large wounds on back mice can regenerate HF a central area reduced expression fibrosis markers (wound induced follicle neogenesis, WIHN), is facilitated by similar pathways anagen activation (Wnt, AKT). Identification modulators entry and WIH...