PURPOSE Adverse drug reactions (ADRs) including medication allergies are not well-described among large national cohorts. This study described the most common documented medication allergies and their reactions among a national cohort of Veterans Affairs (VA) inpatients. METHODS We evaluated inpatient admissions in any VA Medical Center from 1 January 2000 to 31 December 2014. Each admission ...

Investigation of anaphylaxis during general anaesthesia requires an accurate record of events including information on timing of drug administration provided by the anaesthetist, as well as timed acute tryptase measurements. Referrals should be made to a centre with the experience and ability to investigate reactions to a range of drug classes/substances including neuromuscular blocking agents ...

In order to study the flare-up of contact allergy, 35 patients with a contact allergy to gold were given an intramuscular injection of 10 mg gold sodium thiomalate, i.e. the anti-rheumatic drug Myocrisin. Clinical reactions comprised an eczematous flare-up of previously positive patch tests to gold and of a previous dermatitis, which occurred in 80% and 26%, respectively; a toxicoderma-like ras...

Fixed drug eruption (FDE) is typically establishes as round or oval, sharply delineated erythematous edematous plaques. Essentially it a drug-induced cutaneous reaction that happens at the similar site with each exposure to specific medication. A extensive spectrum of drugs can occasionally give rise numerous contrary orofacial manifestations, predominantly dry mouth, taste disturbances, oral m...

Patient allergies are documented in multiple areas of the electronic health records (EHRs) including beyond allergy list (e.g., notes, laboratory tests, and flowsheets). Systematically reconciling information is critical to improve accuracy EHR facilitate clinical decision support maintain patient safety. Our retrospective study included all patients who visited Mass General Brigham (MGB) 2018....

Adverse reactions may occur with any of the medications prescribed or administered in dental practice. Most of these reactions are somewhat predictable based on the pharmacodynamic properties of the drug. Others, such as allergic and pseudoallergic reactions, are less common and unrelated to normal drug action. This article will review the most common adverse reactions that are unrelated to dru...

BACKGROUND Penicillin is the most common drug "allergy" noted at hospital admission, although it is often inaccurate. OBJECTIVE We sought to determine total hospital days, antibiotic exposures, and the prevalence rates of Clostridium difficile, methicillin-resistant Staphylococcus aureus (MRSA), and vancomycin-resistant Enterococcus (VRE) in patients with and without penicillin "allergy" at h...

INTRODUCTION Patients who have an adverse drug reaction are frequently labelled drug allergic without undergoing proper evaluation and confirmatory testing. These drug allergy labels may be inaccurate, leading to unnecessary lifelong avoidance. The aim of this study was to review the patients that underwent drug provocation tests (DPTs) in our centre and examine the usefulness of DPTs in confir...