Co-delivery approach has been recommended to reduce the amount of each drug and to achieve the synergistic effect for cancer treatment. CUR and SF have antitumor effects, but their application is limited because of their low water solubility and poor oral bioavailability. To improve the bioavailability and solubility of SF and CUR, we performed an innovative co-delivery of SF and CUR with magne...

Perhexiline maleate is an antianginal agent which depends on hepatic oxidation for its elimination. Its use may be complicated by the development of peripheral neuropathy and liver damage. The majority of patients with perhexiline neuropathy have an impaired ability to effect metabolic drug oxidation which is genetically determined. Information has not been available on drug oxidation capacity ...

Drug resistance represents one of the main problems for the use of chemotherapy to treat leishmaniasis. Additionally, it could provide some advantages to Leishmania parasites, such as a higher capacity to survive in stress conditions. In this work, in mixed populations of Leishmania donovani parasites, we have analyzed whether experimentally resistant lines to one or two combined anti-leishmani...

The U.S. joint military medical community has an increasing role in collaborative health sector engagement internationally as part of a whole of government approach to successful operations. The military must master the ability to catalyze health sector gains that can be developed by hosts, U.S. Government, and international agencies in both permissive environments and conflict zones. Capacity ...

We study the one-shot zero-error classical capacity of quantum channels assisted by quantum non-signalling correlations, and the reverse problem of simulation. Both lead to simple semi-definite programmings whose solutions can be given in terms of the conditional min-entropies. We show that the asymptotic simulation cost is precisely the conditional min-entropy of the Choi-Jamiołkowski matrix o...

Motivated by channel measurements in different indoor locations we will show that the WLAN indoor MIMO channel is characterized by few dominant transmission paths mainly corresponding to the LOS path and some strong reflections. In the contrary to the common statistical flat Rayleigh fading channel model we will explain that the WLAN channel is widely deterministic and frequency selective. Furt...

topical drug dosage forms such as ointments and creams can be easily removed through wetting, movement and contact. the new bioadhesive formulations with enhanced local anesthetic effects are needed for topical administration. the adhesive capacity of hydroxypropyl methylcellulose (hpmc) was determined by measuring the maximum detachment force and the adhesion work with an auto peeling tester. ...

Cisplatin continues to be a first line chemotherapy agent alone or in combination with other cytotoxic agents orradiotherapy. Dose-limiting side effects, intrinsic and acquired resistance are the main reasons for inventing and developing new ways of delivering cisplatin. Biocompatible hollow porous materials offer high void volume, shell porosity, low density and controllable size which make th...