To mimic multilevel nerve root compression and intervertebral foramina stenosis in human, we established a new animal model of the chronic compression of unilateral multiple lumbar DRGs (mCCD) in the rat. A higher occurrence of signs of spontaneous pain behaviors, such as wet-dog shaking and spontaneous hind paw shrinking behaviors, was firstly observed from day 1 onward. In the meantime, the u...

Lipid profiles of seven human breast milk samples obtained from milk banks and four infant formulas were compared in view of the potential food hypersensitivities of certain infants to human milk.The cholesterol (0.15-0.26 mM) content of the human samples was about 50% lower than that found in the infant formulas whereas the triglyceride (TG, 173-386 mM) contents of these products were found to...

OBJECTIVE The aim of the present study was to clinically evaluate the effect of two different adhesive/resin composite combinations for luting of IPS Empress inlays. METHODS Ninety-four IPS Empress restorations were placed in 31 patients in a controlled prospective clinical split-mouth study. The restorations were luted with EBS Multi/Compolute (3M Espe) or with Syntac/Variolink II low (Ivocl...

Background. Models of cancer-induced neuropathy are designed by injecting cancer cells near the peripheral nerves. The interference of tissue-resident immune cells does not allow a direct contact with nerve fibres which affects the tumor microenvironment and the invasion process. Methods. Anaplastic tumor-1 (AT-1) cells were inoculated within the sciatic nerves (SNs) of male Copenhagen rats. Lu...

the present study is aimed at the overall improvement in the efficacy, reduced toxicity and enhancement of therapeutic index of cisplatin. nanocapsules of cisplatin containing ethylcellulose have been prepared using solvent evaporation technique under ambient conditions. the prepared nanocapsules were used for controlled drug release of anticancer agents with gold and iron oxide nanoparticles. ...

normal 0 false false false en-us x-none ar-sa microsoftinternetexplorer4 drug‑drug interactions (ddis) are one of the commonest causes of medication error in developed countries, particularly in the elderly due to poly‑therapy, with a prevalence of 20‑40%. in particular, poly‑therapy increases the complexity of therapeutic management and thereby the risk of clinically important ddis, wh...

• The authors have no financial conflicts of interest. which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The sulfites are widely used as anti-browning agents and preservatives in food, cosmetics and medicine. The use and amount of sulfites in products have recently been regulated by the Food and Drug Admini...

Sir: Clozapine is an antipsychotic medication introduced to the United States in 1989. It is a tricyclic dibenzodiazepine derivative chemically related to the traditional antipsychotic medication loxapine. 1 Side effects pose a significant problem during clozapine therapy. Adverse reactions occur most frequently during the initiation of clozapine treatment and during the acute treatment and dos...

Sir: Clozapine is an antipsychotic medication introduced to the United States in 1989. It is a tricyclic dibenzodiazepine derivative chemically related to the traditional antipsychotic medication loxapine. 1 Side effects pose a significant problem during clozapine therapy. Adverse reactions occur most frequently during the initiation of clozapine treatment and during the acute treatment and dos...

We previously reported that gelsolin gene expression is reduced in various tumors. In an effort to gain further insights into the mechanism of gelsolin downregulation in tumors, we examined the in vivo properties of the gelsolin promoter in urinary bladder cancer cell lines. Neither mutation nor hypermethylation was responsible for gene silencing at the promoter. After exposure to trichostatin ...