Non-fatal overdose is an occupational risk of heroin misuse' and fatal overdose is a common cause of premature death in heroin users. ... One of the major contributors to a fatal outcome is the inadequacy of heroin users' responses to the overdoses of their peers. They may delay calling an ambulance for fear of the police arriving, and their efforts to revive comatose users are often ineffectiv...

Opioid dependence and overdose have increased to epidemic levels in the United States. The 2014 National Survey on Drug Use and Health estimated that 4.3 million persons were nonmedical users of prescription pain relievers (1). These users are 40 times more likely than the general population to use heroin or other injection drugs (2). Furthermore, CDC estimated a near quadrupling of heroin-rela...

The heroin epidemics that spread across Europe in the 1980s resulted in increasing numbers of overdose deaths among opioid users (). Although the annual number of reported deaths peaked around the turn of the millennium, drug overdose still claimed more than 70 000 lives in Europe in the subsequent decade. Contrary to the promising overall trend between 2009 and 2013, when the number of reporte...

INTRODUCTION Drug overdose is the most frequent cause of death among people who misuse illegal drugs. People who inject these drugs are 14-17 times more likely to die than their non-drug using peers. Various strategies to reduce drug-related deaths have failed to meet target reductions. Research into community-based interventions for preventing drug overdose deaths is promising. This review see...

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Abstract: Amlodipine is a dihydropyridine calcium channel blocker mainly indicated in the treatment of essential hypertension and angina pectoris. Overdose blocker, results toxicity along with profound hypotension shock. Here, 20-year-old female patient was admitted to MICU complaints severe breathing difficulty, multiple episodes vomiting one day earlier. After chest x-ray, ECG, blood investig...

BACKGROUND Illicit drug overdose remains a leading cause of premature mortality in urban settings worldwide. We sought to estimate the number of deaths potentially averted by the implementation of a medically supervised safer injection facility (SIF) in Vancouver, Canada. METHODOLOGY/PRINCIPAL FINDINGS The number of potentially averted deaths was calculated using an estimate of the local rati...

BACKGROUND While it is certain that some emergency department patients with acute drug overdose suffer adverse cardiovascular events (ACVE), predicting ACVE is difficult. The prognostic utility of the ECG for heterogeneous drug overdose patients remains to be proven. This study was undertaken to validate previously derived features of the initial ECG associated with ACVE in this population. M...

Paracetamol is the commonest drug taken in overdose in the United Kingdom. While the management of early paracetamol poisoning is straightforward, the management of late presenting cases, cases presenting after a staggered overdose, and patients with risk factors for paracetamol poisoning can be much more complex. The authors have developed and present here an evidence based flowchart that will...