Background & Aims: Allergic reaction is a common side effect of Efavirenz and drug replacement may not be an option to physicians. Here, a successful drug desensitization experiment on an 8-year-old female child over a period of 9 days is reported. Case presentation: The patient was an 8-year old female child with HIV in Kerman, Iran who had been received oral efavirenz together with lamivudine...

with the aim of obtaining information about drug-drug interaction (ddi) between acetaminophen and some of antidepressant drugs (fluoxetine, sertraline and nortriptyline), in the present work we studied the electrochemical oxidation of acetaminophen (paracetamol) in the presence of these drugs by means of cyclic voltammetry and controlled-potential coulometry. the reaction between n-acetyl-p-ben...

Abstract A 46-year-old man was referred for investigation of an acute widespread rash and fever that started 4 weeks after commencing citalopram. Clinical histological features were consistent with drug reaction eosinophilia systemic (DRESS). He not on any other medication, had no known allergies previously taken a selective serotonin reuptake inhibitor (SSRI). Six months resolution, he patch t...

In this paper we develop an optimization approach for the study of adverse drug reaction (ADR) problems. This approach is based on drug–reaction relationships represented in the form of a vector of weights, which can be defined as a solution to some global optimization problem. Although it can be used for solving many ADR problems, we concentrate on two of them here: the accurate identification...

UNLABELLED INTRODUCTION Drug reaction with eosinophilia and systemic symptoms syndrome is a potentially life-threatening hypersensitivity reaction with rash, fever, and internal organ involvement, often hepatitis, occurring most commonly two to eight weeks after initiation of a medication. The present case is an example of severe and potentially life-threatening hepatitis as a manifestation ...

Tuberculosis (TB) is a communicable disease caused by the bacillus Mycobacterium tuberculosis and leading cause of death single infectious agent overall. According to WHO Global TB Report, India contributes 26% global burden TB. Currently, four-drug regimen comprising Rifampicin, Isoniazid, Pyrazinamide, Ethambutol approved for treatment drug-sensitive The management cutaneous adverse drug reac...

abstract fixed drug eruption (fde) is a unique type of cutaneous drug reaction that typically recurs in the identical locations on re-exposure to the attributed drug. fde is characterized by the appearance of a single or multiple sharply demarcated violaceous erythematous plaques which heal with residual hyperpigmentation. a 27-year-old woman presented with multiple dark patches over her eyelid...

discussion early recognition of dress syndrome is of a particular importance. although rare, in newborn infants with the presence of skin rash, liver involvement, hyper-eosinophilia and lymphadenopathy, dress diagnosis should be highly suspected and prompt intervention including withdrawal of causative drug is required to prevent potentially fatal outcomes. introduction drug rash with eosinophi...

Causality Assessment of Suspected Adverse Drug Reaction with Anti-Tubercular Therapy by WHO Probability ScaleS. Yadav, K.K. Pillai, P. Kapur