conclusions hcv gpe2 is an ideal target for hcv vaccine. prediction of epitope immunogenicity and characterization on the basis of peptide sequences will be significantly helpful for development of a heterologous vaccine against hcv variants. results many b-cell and t-cell epitopes predicted in gpe2 were found conserved among hcv 3a genotypes whereas few were conserved in other genotypes antici...

Multidrug resistance (MDR) is a generic term for the variety of strategies tumor cells use to evade the cytotoxic effects of anticancer drugs. MDR is characterized by a decreased sensitivity of tumor cells not only to the drug employed for chemotherapy but also to a broad spectrum of drugs with neither obvious structural homology nor common targets. This pleiotropic resistance is one of the maj...

Abstract This paper is intended to introduce a filtration analysis of sampled maps based on persistent homology, providing new method for reconstructing the underlying maps. The key idea extend definition homology induced correspondences using framework quiver representations. Our given by most direct summands uniquely determine homology. We provide stability theorems this process and show that...

Boukharta, L. 2014. Computational Modelling of Ligand Complexes with G-Protein Coupled Receptors, Ion Channels and Enzymes. Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology 1105. 61 pp. Uppsala: Acta Universitatis Upsaliensis. ISBN 978-91-554-8823-9. Accurate predictions of binding free energies from computer simulations are an invaluable resou...

Epigenetic dysfunction has been widely implicated in several diseases especially cancers thus highlights the therapeutic potential for chemical interventions in this field. With rapid development of computational methodologies and high-performance computational resources, computer-aided drug design has emerged as a promising strategy to speed up epigenetic drug discovery. Herein, we make a brie...

BACKGROUND Both intrinsic and acquired multidrug resistance play an important role in the insurgence of tuberculosis. Detailed knowledge of the molecular basis of drug recognition and transport by multidrug transport systems is required for the development of new antibiotics that are not extruded or of inhibitors that block the multidrug transporter and allow traditional antibiotics to be effec...

Generation of three dimensional structures of macromolecules using in silico structural modeling technologies such as homology and de novo modeling has improved dramatically and increased the speed by which tertiary structures of organisms can be generated. This is especially the case if a homologous crystal structure is already available. High-resolution structures can be rapidly created using...

Let B be a commutative algebra and A B-algebra (determined by an homomorphism ?:B?A). M. D. Staic introduced Hochschild like cohomology H•((A,B,?);A) called secondary cohomology, to describe the non-trivial deformations of A. J. Laubacher et al later obtained natural construction new chain complex C¯•(A,B,?) in process introducing cyclic (co)homology. In this paper, we establish connection betw...

We prove that every [Formula: see text]H-thin link has no text]-torsion for text] in its Khovanov homology. Together with previous results by Lee [The support of the Khovanov’s invariants alternating knots, preprint (2002), arXiv:math.GT/0201105; An endomorphism invariant, Adv. Math. 197(2) (2005) 554–586, arXiv:math.GT/0210213] and author [Torsion homology, Fund. 225 (2014) 343–364, arXiv:math...