Abstract Background Several methods are used to account for various hospital characteristics when comparing antimicrobial use (AU) between heterogenous hospitals. Recently, a new stewardship metric that adjusts AU by microbiological burden (a-AU) of the bacteria was proposed (Figure 1). It accounts resistant phenotypes observed at given institution, allowing more balanced comparison across This...

One considers systems made of synchronizers to which distributed reactive machines are connected. The corresponding model is described with its implementation in Java, using SugarCubes and the RMI mechanism. Key-words: Reactive Systems, Distribution, SugarCubes, Java, RMI With support from France Telecom-CNET EMP-CMA/INRIA Meije y CNET DTR/ASR

Serum IL-6 is increased in acute kidney injury (AKI) and inhibition of IL-6 reduces AKI-mediated lung inflammation. We hypothesized that circulating monocytes produce IL-6 and that alveolar macrophages mediate lung inflammation after AKI via chemokine (CXCL1) production. To investigate systemic and alveolar macrophages in lung injury after AKI, sham operation or 22 min of renal pedicle clamping...

BACKGROUND Environmental factors such as temperature can alter mosquito vector competence for arboviruses. Results from recent studies indicate that daily fluctuations around an intermediate mean temperature (26°C) reduce vector competence of Aedes aeygpti for dengue viruses (DENV). Theoretical predictions suggest that the mean temperature in combination with the magnitude of the diurnal temper...

Rodent models of arthritis have been extensively used in the elucidation of rheumatoid arthritis (RA) pathogenesis and are instrumental in the development of therapeutic strategies. Here we utilise delayed-type hypersensitivity arthritis (DTHA), a model in C57BL/6 mice affecting one paw with synchronised onset, 100% penetrance and low variation. We investigate the role of regulatory T cells (Tr...

Defined as the difference between daily maximum (Tmax) and minimum surface air temperature (Tmin), diurnal range (DTR) is critical to local climate, ecosystem, socio-economic functioning. This study investigates how DTR responds future global warming, using a novel, fine-resolution convection-permitting regional climate model. Results demonstrate asymmetrical impact of that is, more substantial...

Abstract Background Several new β-lactam antibiotics were recently developed for treatment of serious infections due to gram-negative bacteria (GNB) with difficult-to-treat resistance (DTR). This multicenter retrospective cohort study examined temporal trends in prevalence GNB DTR and the use β-lactams southeastern United States. Methods The DTR, including Enterobacterales, Pseudomonas aerugino...