Geambasu A, Krukoff TL. Adrenomedullin acts in the lateral parabrachial nucleus to increase arterial blood pressure through mechanisms mediated by glutamate and nitric oxide. Am J Physiol Regul Integr Comp Physiol 295: R38–R44, 2008. First published May 21, 2008; doi:10.1152/ajpregu.00172.2008.—Adrenomedullin (ADM) acts in a site-specific manner within autonomic centers of the brain to modulate...

PURPOSE To explore the effects of hypoxia on the production and secretion of adrenomedullin (ADM) and endothelin (ET)-1 in human retinal pigment epithelial (RPE) cells. METHODS RPE cells were cultured under normoxic or hypoxic (1% O2) conditions. Expression of ADM and ET-1 was examined by Northern blot analysis and radioimmunoassay. Effects of ADM and ET-1 on the number of RPE cells were exam...

Macrophages secrete a variety of growth factors, cytokines and vasoactive peptides, which are related to the progression of atherosclerosis. Adrenomedullin (ADM) is a potent vasodilator peptide and inhibits proliferation and migration of vascular smooth muscle cells. In this study, we investigated the production and secretion of ADM by monocytes and macrophages by Northern blot analysis, RIA an...

Plasma concentrations of the recently discovered hormones adrenomedullin (ADM), from vascular tissue, and brain natriuretic peptide (BNP), secreted by myocardium, are elevated in patients with heart failure. We tested the hypotheses that short-term increments in circulating levels of these hormones, within the pathophysiological range, would have biological effects and that the 2 hormone system...

Use of human acellular dermal matrix (ADM) during prosthetic breast reconstruction has increased. Several ADM products are available produced by differing manufacturing techniques. It is not known if outcomes vary with different products. This study reports the complication prevalence following use of a tutoplast-derived ADM (T-ADM) in prosthetic breast reconstruction. We performed a retrospect...

Amyopathic dermatomyositis (ADM) is a clinical subtype of dermatomyositis, characterized by the lack of motor weakness and the presence of normal muscle enzyme levels. ADM is sometimes accompanied by interstitial pneumonia that shows a rapid progressive course associated with a poor prognosis. We report a 49-year-old patient who presented with nonspecific interstitial pneumonia (NSIP) associate...

Resistance to chemotherapeutic agents is the main reason for treatment failure in patients with cancer. The primary mechanism of multidrug resistance (MDR) is the overexpression of drug efflux transporters, including ATP‑binding cassette transporter G2 (ABCG2). To the best of our knowledge, the MDR mechanisms of esophageal cancer have not been described. An adriamycin (ADM)-resistant subline, Ec...

We consider a family of high accuracy, approximate deconvolution models of turbulence. For body force driven turbulence, we prove directly from the models equations of motion the following bounds on the model’s time averaged energy dissipation rate, < "ADM >, and helicity dissipation rate, < ADM (w) >; < "ADM > 2 U3 L +Re 1 U3 L (1 + ( L )) , and j < ADM (w) > j U3 L2 + p 2Re 1 2 (1 + 2 L2 ) 1 ...

INTRODUCTION Adrenomedullin (ADM), a circulating vasodilatory peptide, plays an important role in the development of sepsis-associated hemodynamic and microcirculatory disorders. While administration of exogenous ADM had beneficial effects in several septic animal models, elevated ADM concentrations are associated with a bad outcome. This prompted us to test the effect of various anti-ADM antib...

Neutral and negatively charged liposomes containing Adria mycin (ADM) were examined for the efficiency of drug entrap ment, serum stability, in vivo tissue distribution, and tumorinhibitory activity. Entrapment of ADM in negatively charged liposomes containing phosphatidylserine (PS) or cardiolipin (DPG) was 3to 4-fold higher than in neutral phosphatidylcholine (PC) liposomes with or without ch...