PURPOSE The aim of this study was to evaluate the expression of cyclooxygenase-2 in human breast cancer using immunohistochemistry and to determine whether the expression of cyclooxygenase-2 is associated with clinicopathological factors in invasive ductal breast carcinoma. METHODS Cyclooxygenase-2 expression was investigated by immunohistochemistry in 30 invasive ductal breast carcinoma spec...

AIMS To determine if allelic loss on chromosomes 16q and 17p, commonly encountered in in situ and invasive ductal carcinomas, is present in atypical ductal hyperplasia (ADH); to determine whether ADH is a neoplastic (clonal) or hyperplastic (polyclonal) proliferation. METHODS Fourteen cases of ADH were examined for allele loss at loci on chromosome 16q and 17p using a microdissection techniqu...

OBJECTIVE The majority of the tumors in periampullary region are pancreatic and ampulla of Vater carcinomas. The aim of this study was to compare histopathological features of ampulla of Vater carcinomas with pancreatic ductal adenocarcinomas and to determine diagnostic and predictive values of p16 protein and cyclin D1 expression. MATERIAL AND METHOD Tissue samples from pancreatic ductal ade...

Background: The breast cancer is the most prevalent cancer among women, on the other hand absence of myoepithelial cells play a pivotal role in pathogenesis of this cancer. Thus we aimed to investigate the possible abilities of the molecular assay technique to find a relationship between mammary serine protease inhibitor (Maspin) gene expression possibly secreted by my...

Morphological criteria for the diagnosis of intraductal proliferative lesions of the breast have been an object of research and much controversy, and its terminology is rather confusing. Knowledge of the molecular aspects of this disease probably necessitates further research to clarify if these entities can be identified as breast cancer precursors or as a malignant preinvasive disease. These ...

Background: Invasive ductal carcinoma is the most common type of breast cancer in Iran. Impaired immune responses occur frequently in cancer patients, but the mechanisms of the induced immune defects remain poorly understood. It is believed that infiltrated immune cells, especially macrophages, may provide help for tumor cell growth and metastasis.   Objective: To analyze the status of tumor as...

Introduction: Breast cancer is the most common cause of Cancer-related death among women. The aim of this study was to assess the pathologic findings of patients with breast cancer who were referred to the pathology ward in Bandarabbas during 2002 to 2010. Methods and Materials: In this descriptive study in 2010, all patients with breast cancer who were referred to the pathology ward of Banda...

When a total of 2488 Turkish patients were taken into consideration, carcinomas with apocrine differentiation accounted for 0.7% of invasive breast carcinomas. The aim of this study was to evaluate clinicopathologic features of this rare type breast carcinoma in Turkish population. To our knowledge, our study has a unique specialty as having broadest group of Turkish patients with apocrine carc...