BACKGROUND We critically evaluated the available evidence on genomic tests in breast cancer to define their prognostic ability and likelihood to determine treatment benefit. DESIGN Independent evaluation of six genomic tests [Oncotype Dx™, MammaPrint(®), Genomic Grade Index, PAM50 (ROR-S), Breast Cancer Index, and EndoPredict] was carried out by a panel of experts in three parameters: analyti...

Background: Innovation is a critical success factor of digital transformation (DX). Previous research has shown that open innovation (OI) can help companies accelerate DX and improve their business performance. Objective: This study develops conceptual OI framework to support (OIDX) provides an overview the dimensions. in this refers Open 2.0. Methods: We review previous on dimensions, identify...

We consider three examples of weekly perturbed centers which do not have geometrical equivalence: a linear center, a degenerate center and a non-hamiltonian center. In each case the number and amplitude of the limit cycles emerging from the period annulus are calculated following the same strategy: we reduce of all of them to locally equivalent perturbed integrable systems of the form: dH(x, y)...

Electromagnetic (EM) wave scattering by many parallel infinite cylinders is studied asymptotically as a → 0, where a is the radius of the cylinders. It is assumed that the centers of the cylinders x̂m are distributed so that N (∆) = ln( 1 a ) ∫ ∆ N(x)dx[1 + o(1)], where N (∆) is the number of points x̂m = (xm1, xm2) in an arbitrary open subset of the plane xOy, the axes of cylinders are parallel ...

A (convex) polytope is the convex hull of finitely many points in Rd. Alternatively, a polytope can be defined as the bounded intersection of finitely many halfspaces, that is, a polytope is the (bounded) solution set of a system of linear equations and inequalities. (This latter fact is the main non-geometric reason why people are interested in polytopes—linear systems are everywhere.) The mai...

O and Si donors in GaN are studied by Raman spectroscopy under hydrostatic pressure p. The ground state of O is found to transfer from a shallow level to a deep gap state at p . 20 GPa reminiscent of DX centers in GaAs. Transferred to AlxGa12xN we predict that O induces a deep gap state for x . 0.40. In GaN:Si no such state is induced up to the highest pressure obtained sp ­ 25 GPad equivalent ...

Percutaneous skin prick tests (SPT) have been considered the preferred method for confirming IgE-mediated sensitization. This reliable and minimally invasive technique correlates with in vivo challenges, has good reproducibility, is easily quantified, and allows analyzing multiple allergens simultaneously. Potent extracts and a proficient tester improve its accuracy. Molecular-based allergy dia...

Exposure to glucocorticoids leads to numerous changes in various biological systems including the reproductive system. The aim of the present work was to find out whether dexamethasone (Dx) treatment of adult female rats would influence the histological and morphometric characteristics of the pituitary gonadotrophic cells (luteinizing--LH cells and follicle stimulating--FSH cells). One group of...

Growth hormone (GH) and glucocorticoids have a powerful influence on controlling fetal growth, differentiation and maturation of numerous tissues. In the present study, the effect of maternal dexamethasone (Dx) treatment on GH cells and body weight in 19- and 21-day-old rat fetuses was investigated using immunocytochemical and morphometric methods. Pregnant female rats received daily injections...