Motorcycle exhaust particulates (MEP) contain carcinogenic polycyclic aromatic hydrocarbons including benzo(a)pyrene. This study has determined the ability of MEP to alter the expression of select genes from drug metabolism, cytokine, oncogene, tumor suppressor, and estrogen signaling families of human lung adenocarcinoma CL5 cells. cDNA microarray analyses and confirmation studies were perform...

A probabilistic information retrieval method using the Maxfrom Kantor, 1994), or (b) useful for information retrieval, imum Entropy Principle (MEP) was proposed by Cooper even if it is not true. In the present article, we examine these and Huizinga (1982). Several refinements of the MEP for questions using the TREC5 (Harman, 1996, in press) biinformation retrieval have been proposed by Kantor a...

Title of Document: NEW INSIGHT INTO ISOPRENOID BIOSYNTHESIS IN THE CYANOBACTERIUM SYNECHOCYSTIS SP. STRAIN PCC 6803 Kelly Ann Poliquin, Doctor of Philosophy, 2006 Directed By: Professor Elisabeth Gantt, Department of Cell Biology and Molecular Genetics In cyanobacteria, many compounds including chlorophylls, carotenoids, and quinones are synthesized from the isoprenoid precursors isopentenyl di...

OBJECTIVE To investigate whether motor evoked potential (MEP) amplitude ratio measurements are sufficiently objective to assess functional activities of the extremities. We also delineated the distribution between the presence or absence of MEPs and the Medical Research Council (MRC) scale for muscle strength of the extremities. METHODS We enrolled 183 patients with first-ever unilateral hemi...

Inspiratory loading in awake humans is associated with electroencephalographic signs of supplementary motor area (SMA) activation. To provide evidence for a functional connection between SMA and the diaphragm representation in the primary motor cortex (M1(DIA)), we tested the hypothesis that modulating SMA activity using repetitive transcranial magnetic stimulation (rTMS) would alter M1(DIA) ex...

Plants have two isoprenoid biosynthetic pathways: the cytosolic mevalonate (MVA) pathway and the plastidic 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway. Since the discovery of the MEP pathway, possible metabolic cross-talk between these pathways has prompted intense research. Although many studies have shown the existence of such cross-talk using feeding experiments, it remains to be deter...

Multi Expression Programming (MEP) [17, 18, 24, 25] is a Genetic Programming variant that uses a linear representation of chromosomes. MEP individuals are strings of genes encoding complex computer programs. When MEP individuals encode expressions, their representation is similar to the way in which compilers translate C or Pascal expressions into machine code [2]. A unique MEP feature is the a...

The cooperation of the mevalonate (MVA) and methylerythritol phosphate (MEP) pathways, operating in parallel in plants to generate isoprenoid precursors, has been studied extensively. Elucidation of the isoprenoid metabolic pathways is indispensable for the rational design of plant and microbial systems for the production of industrially valuable terpenoids. Here, we describe a new method, base...

BACKGROUND Neuroimaging studies of chronic smokers report altered activity of several neural regions involved in the processing of rewarding outcomes. Neuroanatomical evidence suggests that these regions are directly connected to the tongue muscle through the corticobulbar pathways. Accordingly, we examined whether corticobulbar excitability might be considered a somatic marker for nicotine cra...

The long-overlooked methylerythritol phosphate (MEP) pathway represents an alternative to the mevalonate route for the formation of isoprene units. It is found in most bacteria as well as in the plastids of all phototrophic organisms. A selection of significant steps of its discovery and elucidation are presented in this contribution, as well as a complete hypothetical biogenetic scheme for the...