Stem cell derived cardiomyocytes generated either from human embryonic stem cells (hESC-CMs) or human induced pluripotent stem cells (hiPSC-CMs) hold great promise for the investigation of early developmental processes in human cardiomyogenesis and future cell replacement strategies. We have analyzed electrophysiological properties of hESC-CMs (HES2) and hiPSC-CMs, derived from reprogrammed adu...

In recent years, human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) have emerged as a vital cell source for in vitro modeling of genetic cardiovascular disorders, drug screening, and in vivo cardiac regeneration research. Looking forward, the ability to efficiently cryopreserve hPSC-CMs without compromising their normal biochemical and physiologic functions will dramatically facilita...

Colistin methanesulfonate (CMS) has the potential to hydrolyze in aqueous solution to liberate colistin, its microbiologically active and more toxic parent compound. While conversion of CMS to colistin in vivo is important for bactericidal activity, liberation of colistin during storage and/or use of pharmaceutical formulations may potentiate the toxicity of CMS. To date, there has been no info...

Colistin, administered intravenously as its inactive prodrug colistin methanesulfonate (CMS), is increasingly used as last-line therapy to combat multidrug-resistant Gram-negative bacteria. CMS dosing needs to be adjusted for renal function. The impact of continuous ambulatory peritoneal dialysis (CAPD) on the pharmacokinetics of both CMS and colistin has not been studied. No CMS dosing recomme...

This document gives a comprehensive overview of the data grid system that CMS intends to operate around December 2003. This CMS data grid system will support both CMS production and analysis and will seamlessly tie together resources at CERN and at international CMS regional centers. This document focuses on the relation between the CMS software components and the grid software components opera...

In spite of many researches in literature investigating dynamic of cell formation (CF) problem, further research needs to be elaborated to assay hidden aspects of cellular manufacturing system (CMS), due to inherent complexity and uncertainty on optimizing this problem. In this paper, sensitivity analysis of modified self-adaptive differential evolution (MSDE) algorithm is proposed for basic pa...

Some properties of a 90% C2H2F4 gas mixture, used to operate resistive plate chambers in avalanche mode, are determined by comparing the experimental results with the prediction of simple analytical calculations. The fast charge distribution of the signal induced on pick-up electrodes is reproduced by means of a Monte Carlo simulation of the avalanche development. In addition predictions for a ...

Genes involved in the fenility restoration (llf) ofwild-abortive (WA)-type cytoplasmic male sterility (CMS) in rice have not been clearly identified, because of the inconsistency of their number and map position, Although the IILI genes, which restore Chinsurah Boro (BT)-type CMS, have been recently isolated, their efi fects on WA-type CMS are still unclear, In the present study, near-isogenic ...

In order to effectively manage organizational information assets, more and more organizations are beginning to implement content management systems (CMS) to consolidate multiple information sources into a single, centralized repository. While organizations implement CMS in attempts to help employees easily identify information sources and quickly locate relevant organizational documents, prior ...

This thesis presents studies related to track-based alignment for the future CMS experiment at CERN. Excellent geometric alignment is crucial to fully benefit from the outstanding resolution of individual sensors. The large number of sensors makes it difficult in CMS to utilize computationally demanding alignment algorithms. A computationally light alignment algorithm, called the Hits and Impac...