ackground & Aims: The aim of this study was to ssess systematically the efficacy of proton pump inhibtors (PPIs) in the treatment of functional dyspepsia ompared with placebo and to determine if any differnce in the response exists between symptom subgroups f functional dyspepsia. Methods: A literature search as performed through September 2005 in PubMed, Medine, Embase, CINAHL, and Cochrane da...

BACKGROUND Helicobacter pylori eradication therapy is routinely used for treating patients with peptic ulcer disease. AIMS To assess the value of symptomatic response to H pylori eradication therapy as a marker of post-treatment H pylori status. PATIENTS AND METHODS One hundred and nine dyspeptic patients with active duodenal or gastric ulceration association with H pylori infection had the...

OBJECTIVES To verify whether symptoms reported by patients with uninvestigated dyspepsia might be helpful in either classifying functional from organic dyspepsia (1st experiment), or recognising which Helicobacter pylori infected patients may benefit from eradication therapy (2nd experiment). METHODS We compared the performance of artificial neural networks and linear discriminant analysis in...

AIMS To determine the relation among the cytotoxin associated gene (cagA) and vacuolating cytotoxin gene (vacA) status of Helicobacter pylori isolates, the associated clinical diseases, and the severity and pattern of chronic gastritis. METHODS Helicobacter pylori was cultured from gastric biopsies obtained from dyspeptic patients. DNA was extracted from the isolates and the cagA and vacA sta...

BACKGROUND & AIMS The aim of this study was to assess systematically the efficacy of proton pump inhibitors (PPIs) in the treatment of functional dyspepsia compared with placebo and to determine if any difference in the response exists between symptom subgroups of functional dyspepsia. METHODS A literature search was performed through September 2005 in PubMed, Medline, Embase, CINAHL, and Coc...

Due to its prevalence, impact on quality-of-life and the associated significant health resource utilization, dyspepsia is a major healthcare concern. The available management strategies for uninvestigated dyspepsia include prompt endoscopy, the 'test-and-treat' strategy for Helicobacter pylori, and empiric antisecretory therapy. There is consensus that endoscopy should be reserved for patients ...