The mechanistic target of rapamycin (mTOR) is a highly conserved and ubiquitously expressed kinase, which consists of two distinct protein complexes, referred to as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1, coupled to Raptor, and mTORC2, coupled to Rictor, respond to different signals and target different substrates; while mTORC1 is activated by a number of signals, including...

Chlamydia trachomatis is an obligate intracellular pathogen that requires specific essential nutrients from the host cell, one of which is the amino acid tryptophan. In this context interferon gamma (IFNγ) is the major host protective cytokine against chlamydial infections because it induces the expression of the host enzyme, indoleamine 2,3-dioxygenase 1, that degrades tryptophan, thereby rest...